(4-((4-chlorophenyl)thio)-5-((4-methoxyphenyl)sulfinyl)thiophen-2-yl)trimethylsilane

Base Information

• Chemical Name: (4-((4-chlorophenyl)thio)-5-((4-methoxyphenyl)sulfinyl)thiophen-2-yl)trimethylsilane
• CAS No.: 1176869-76-3
• Molecular Formula: C₂₀H₂₁ClO₂S₃Si
• Molecular Weight: 453.122
• Mol file: 1176869-76-3.mol

Synonyms:(4-((4-chlorophenyl)thio)-5-((4-methoxyphenyl)sulfinyl)thiophen-2-yl)trimethylsilane

Chemical Property of (4-((4-chlorophenyl)thio)-5-((4-methoxyphenyl)sulfinyl)thiophen-2-yl)trimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-((4-chlorophenyl)thio)-5-((4-methoxyphenyl)sulfinyl)thiophen-2-yl)trimethylsilane

There total 3 articles about (4-((4-chlorophenyl)thio)-5-((4-methoxyphenyl)sulfinyl)thiophen-2-yl)trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

{5-[(4-methoxyphenyl)sulfinyl]-2-thiophenyl}(trimethyl)silane (1176869-72-9) + S-(4-chlorophenyl)benzene thiosulfonate (1213-40-7) → (4-((4-chlorophenyl)thio)-5-((4-methoxyphenyl)sulfinyl)thiophen-2-yl)trimethylsilane (1176869-76-3)

Guidance literature:

{5-[(4-methoxyphenyl)sulfinyl]-2-thiophenyl}(trimethyl)silane; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at -30 ℃; for 0.333333h; Inert atmosphere;

S-(4-chlorophenyl)benzene thiosulfonate; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

DOI:10.1039/b907330b

Reference yield:

2-(trimethylsilyl)thiophene (18245-28-8) → (4-((4-chlorophenyl)thio)-5-((4-methoxyphenyl)sulfinyl)thiophen-2-yl)trimethylsilane (1176869-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0 - 25 °C / Inert atmosphere

1.2: -50 - 25 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

2.2: 1 h / 25 °C / Inert atmosphere

With n-butyllithium; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1002/chem.201003657

Reference yield:

p-methoxybenzenesulfinyl chloride (31401-23-7) → (4-((4-chlorophenyl)thio)-5-((4-methoxyphenyl)sulfinyl)thiophen-2-yl)trimethylsilane (1176869-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0 - 25 °C / Inert atmosphere

1.2: -50 - 25 °C / Inert atmosphere

2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

2.2: 1 h / 25 °C / Inert atmosphere

With n-butyllithium; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1002/chem.201003657

upstream raw materials:

{5-[(4-methoxyphenyl)sulfinyl]-2-thiophenyl}(trimethyl)silane

S-(4-chlorophenyl)benzene thiosulfonate

2-(trimethylsilyl)thiophene

p-methoxybenzenesulfinyl chloride

Downstream raw materials:

ethyl 5-[3-[(4-chlorophenyl)thio]-5-(trimethylsilyl)-2-thienyl]nicotinate

ethyl 4-(3-((4-chlorophenyl)thio)-5-(trimethylsilyl)thiophen-2-yl)benzoate

3-((4-chlorophenyl)thio)-5-(trimethylsilyl)thiophene-2-carbaldehyde