N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide
CAS No.:895147-32-7
Molecular Formula:C₁₃H₉F₅N₄O₂
Molecular Weight:348.232
Hs Code.:

Synonyms:N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide

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Chemical Property of N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide

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Technology Process of N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide

There total 2 articles about N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 895147-32-7
N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.66667h;

In N,N-dimethyl-formamide; for 2h;

Reference yield:

: C₇H₆F₃N₃O₃

: 4519-40-8
2,3-difluoroanilline

: 895147-32-7
N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 - 90 ℃; for 5h;

Reference yield: 75.0%

: 895147-32-7
N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide

: 895147-26-9
2-(3-amino-1H-pyrazol-5-yl)-N-(2,3-difluorophenyl)acetamide

Guidance literature:: N-(5-{2-[(2,3-difluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)-2,2,2-trifluoroacetamide; With hydrogenchloride; methanol; water; at 50 ℃; for 3h;

With sodium hydrogencarbonate; In water;