3-{3-[4-(2,6-dihydroxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Base Information

Chemical Name:3-{3-[4-(2,6-dihydroxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil
CAS No.:1296176-98-1
Molecular Formula:C₂₆H₁₈ClFN₄O₁₀
Molecular Weight:600.901
Hs Code.:

Synonyms:3-{3-[4-(2,6-dihydroxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

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Chemical Property of 3-{3-[4-(2,6-dihydroxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

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Technology Process of 3-{3-[4-(2,6-dihydroxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

There total 9 articles about 3-{3-[4-(2,6-dihydroxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1296176-98-1
3-{3-[4-(2,6-dihydroxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere; Cooling

2: thionyl chloride / N,N-dimethyl-formamide / toluene / 4.5 h / 80 °C

3: triethylamine / 1,4-dioxane / 8 h / 20 °C / Cooling with ice

4: hydrogen / palladium(II) hydroxide / 1,4-dioxane / 1 h

With thionyl chloride; hydrogen; sodium hydride; triethylamine; palladium(II) hydroxide; N,N-dimethyl-formamide; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1380098-47-4
C₂₀H₁₆ClNO₃

: 1296176-98-1
3-{3-[4-(2,6-dihydroxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane / 8 h / 20 °C / Cooling with ice

2: hydrogen / palladium(II) hydroxide / 1,4-dioxane / 1 h

With hydrogen; triethylamine; palladium(II) hydroxide; In 1,4-dioxane;

Reference yield:

: 129971-17-1
1-ethoxymethyl-3-m-hydroxycarbonylbenzoyl-5-fluorouracil

: 1296176-98-1
3-{3-[4-(2,6-dihydroxyisonicotinoyloxy)-5-chloro-2-pyridyloxycarbonyl]benzoyl}-1-ethoxymethyl-5-fluorouracil

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

2: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

3: hydrogen / palladium(II) hydroxide / 1,4-dioxane / 1 h

With thionyl chloride; hydrogen; triethylamine; palladium(II) hydroxide; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;