tert-butyl (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

Base Information

• Chemical Name: tert-butyl (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate
• CAS No.: 1258740-11-2
• Molecular Formula: C₂₂H₂₉NO₅S
• Molecular Weight: 419.542
• Mol file: 1258740-11-2.mol

Synonyms:tert-butyl (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

Chemical Property of tert-butyl (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate

There total 1 articles about tert-butyl (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl (S)-2-(1-tosylaziridin-2-yl)acetate (1258740-08-7) + (3-methoxyphenyl)magnesium bromide (36282-40-3) → (E)-4-(toluenesulfonylamino)-but-2-enoic acid tert-butyl ester (1258740-21-4) + tert-butyl (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate (1258740-11-2)

Guidance literature:

tert-butyl (S)-2-(1-tosylaziridin-2-yl)acetate; (3-methoxyphenyl)magnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -40 - 0 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; at 0 ℃; regioselective reaction;

DOI:10.1016/j.tet.2010.09.025

Reference yield: 89.0%

tert-butyl (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate (1258740-11-2) → (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid (1258740-26-9)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tet.2010.09.025

upstream raw materials:

tert-butyl (S)-2-(1-tosylaziridin-2-yl)acetate

(3-methoxyphenyl)magnesium bromide

Downstream raw materials:

(R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid