Benzyl 3-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate

Base Information

Chemical Name:Benzyl 3-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate
CAS No.:1382996-75-9
Molecular Formula:C₂₆H₃₃ClN₂O₅
Molecular Weight:489.011
Hs Code.:

Synonyms:Benzyl 3-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate

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Chemical Property of Benzyl 3-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate

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Technology Process of Benzyl 3-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate

There total 5 articles about Benzyl 3-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1382996-74-8
benzyl 3-[3-(1-aminoethyl)-5-chloro-2-methoxy-6-methylphenyl]azetidine-1-carboxylate

: 1382996-75-9
Benzyl 3-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1382996-75-9
Benzyl 3-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-iodo-succinimide / acetic acid / 18 h / 20 °C

2.1: potassium carbonate / acetone / Reflux

3.1: chloro-trimethyl-silane; ethylene dibromide; zinc / N,N-dimethyl-formamide / 1 h / 40 °C

3.2: 70 °C

4.1: titanium(IV) tetraethanolate; ammonia / ethanol / 0 - 60 °C / Inert atmosphere

4.2: 1 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With titanium(IV) tetraethanolate; N-iodo-succinimide; chloro-trimethyl-silane; ammonia; potassium carbonate; ethylene dibromide; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide; acetone;

Reference yield:

: 292144-86-6
1-(5-chloro-2-hydroxy-3-iodo-4-methylphenyl)ethan-1-one

: 1382996-75-9
Benzyl 3-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}-5-chloro-2-methoxy-6-methylphenyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / Reflux

2.1: chloro-trimethyl-silane; ethylene dibromide; zinc / N,N-dimethyl-formamide / 1 h / 40 °C

2.2: 70 °C

3.1: titanium(IV) tetraethanolate; ammonia / ethanol / 0 - 60 °C / Inert atmosphere

3.2: 1 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With titanium(IV) tetraethanolate; chloro-trimethyl-silane; ammonia; potassium carbonate; ethylene dibromide; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;