(2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid

Base Information

Chemical Name:(2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid
CAS No.:1187162-97-5
Molecular Formula:C₁₉H₂₃NO₃
Molecular Weight:313.397
Hs Code.:

Synonyms:(2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid

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Chemical Property of (2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid

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Technology Process of (2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid

There total 5 articles about (2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

: 1187162-95-3
(2S,3S)-3-(dibenzylamino)-2-hydroxypentanenitrile

: 1187162-97-5
(2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid

Guidance literature:: With hydrogenchloride; In water; at 100 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 1187162-89-5
(S)-benzyl 2-(dibenzylamino)butanoate

: 1187162-97-5
(2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water; methanol / 4 h / 0 - 90 °C / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 0 °C / Inert atmosphere

2.2: 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / -30 °C / Inert atmosphere

4.1: sodium hydrogensulfite / water; 1,4-dioxane / 0.17 h / 0 °C / Inert atmosphere

4.2: 20 °C

5.1: hydrogenchloride / water / 2.5 h / 100 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 93950-06-2
(S)-2-(dibenzylamino)butanoic acid

: 1187162-97-5
(2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / -30 °C / Inert atmosphere

3.1: sodium hydrogensulfite / water; 1,4-dioxane / 0.17 h / 0 °C / Inert atmosphere

3.2: 20 °C

4.1: hydrogenchloride / water / 2.5 h / 100 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydrogensulfite; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;