(2S,3S)-N-cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide

Base Information

Chemical Name:(2S,3S)-N-cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide
CAS No.:1187163-01-4
Molecular Formula:C₂₂H₂₈N₂O₂
Molecular Weight:352.477
Hs Code.:

Synonyms:(2S,3S)-N-cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-N-cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide

Chemical Property:

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Technology Process of (2S,3S)-N-cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide

There total 6 articles about (2S,3S)-N-cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.2%

: 1187162-97-5
(2S,3S)-3-(dibenzylamino)-2-hydroxypentanoic acid

: 765-30-0
Cyclopropylamine

: 1187163-01-4
(2S,3S)-N-cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1187162-89-5
(S)-benzyl 2-(dibenzylamino)butanoate

: 1187163-01-4
(2S,3S)-N-cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water; methanol / 4 h / 0 - 90 °C / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 0 °C / Inert atmosphere

2.2: 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / -30 °C / Inert atmosphere

4.1: sodium hydrogensulfite / water; 1,4-dioxane / 0.17 h / 0 °C / Inert atmosphere

4.2: 20 °C

5.1: hydrogenchloride / water / 2.5 h / 100 °C / Inert atmosphere

6.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1187162-95-3
(2S,3S)-3-(dibenzylamino)-2-hydroxypentanenitrile

: 1187163-01-4
(2S,3S)-N-cyclopropyl-3-(dibenzylamino)-2-hydroxypentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 2.5 h / 100 °C / Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;