4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid

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Chemical Name:4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid
CAS No.:128972-43-0
Molecular Formula:C₄₄H₆₀N₈O₆
Molecular Weight:797.01
Hs Code.:

4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid

Synonyms:4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid

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Chemical Property of 4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid

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Technology Process of 4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid

There total 18 articles about 4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3099-31-8
nicotinyl chloride

: 128972-43-0
4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) 2 h

2: 2 M aq. NaOH / ethanol / 1 h

3: triethylamine, 1-hydroxybenzotriazole (HOBT), ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / 20 °C

4: H₂ / 10percent Pd/C / ethanol / 1 h / 20 °C

With sodium hydroxide; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a005

Reference yield:

: 4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid benzyl ester

: 128972-43-0
4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 1h;
DOI:10.1021/jm00171a005

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 128972-43-0
4-((S)-2-{(3S,4S)-5-Cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 18 h

2: 4 M HCl / dioxane

3: 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 18 h

4: 4 M HCl / dioxane

5: triethylamine, 1-hydroxybenzotriazole (HOBT), ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / 20 °C

6: H₂ / 10percent Pd/C / ethanol / 1 h / 20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a005