3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)propionic acid benzhydryl ester

Base Information

Chemical Name:3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)propionic acid benzhydryl ester
CAS No.:1448674-16-5
Molecular Formula:C₃₆H₃₃N₃O₈
Molecular Weight:635.673
Hs Code.:

Synonyms:3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)propionic acid benzhydryl ester

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Chemical Property of 3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)propionic acid benzhydryl ester

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Technology Process of 3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)propionic acid benzhydryl ester

There total 5 articles about 3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)propionic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 524-38-9
N-hydroxyphthalimide

: 1448674-15-4
3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-hydroxypropionic acid benzhydryl ester

: 1448674-16-5
3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)propionic acid benzhydryl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1448674-12-1
3-(4-carbamimidoylphenoxy)-2-hydroxypropionic acid methyl ester

: 1448674-16-5
3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)propionic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 3.5 h / 20 °C

2: water; sodium hydroxide / tetrahydrofuran / 0.25 h / 0 °C

3: methanol / 20 °C

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

With water; sodium hydrogencarbonate; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; water;

Reference yield:

: 1448674-13-2
3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-hydroxypropionic acid methyl ester

: 1448674-16-5
3-[4-(tert-butoxycarbonylamino-imino-methyl)phenoxy]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yloxy)propionic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / tetrahydrofuran / 0.25 h / 0 °C

2: methanol / 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

With water; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol;