N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Base Information

Chemical Name:N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester
CAS No.:88105-90-2
Molecular Formula:C₂₈H₃₆N₂O₆
Molecular Weight:496.604
Hs Code.:

Synonyms:N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Suppliers and Price of N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

There total 4 articles about N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 86778-86-1
N-(4-phenylbutanoyl)-L-proline

: 16024-44-5
DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester hydrochloride

: 88105-90-2
N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Guidance literature:: With N-Ethylmaleimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 25 ℃; for 72h; pH 7.0-7.5;
DOI:10.1021/jm00369a017

Reference yield:

: 18496-54-3
phenylbutyric acid chloride

: 88105-90-2
N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / pyridine / CH₂Cl₂ / 3 h / 25 °C

2: 79 percent / H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

3: 98 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

With pyridine; N-Ethylmaleimide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00369a017

Reference yield:

: 88105-73-1
N-(4-phenylbutyryl)-L-proline benzyl ester

: 88105-90-2
N-(4-phenylbutyryl)-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

2: 98 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

With N-Ethylmaleimide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00369a017