1-(5-O-(DIMETHOXYTRITYL)-BETA-D-2-DEOXYRIBOFURANOSYL)-3-NITROPYRROLE

Base Information

• Chemical Name: 1-(5-O-(DIMETHOXYTRITYL)-BETA-D-2-DEOXYRIBOFURANOSYL)-3-NITROPYRROLE
• CAS No.: 166984-63-0
• Molecular Formula: C30H30 N2 O7
• Molecular Weight: 530.57
• Mol file: 166984-63-0.mol

Synonyms:

Chemical Property of 1-(5-O-(DIMETHOXYTRITYL)-BETA-D-2-DEOXYRIBOFURANOSYL)-3-NITROPYRROLE

Chemical Property:

• PSA: 107.90000
• LogP: 5.59380

Purity/Quality:

97% ^*data from raw suppliers

1-(5-OXO-(DIMETHOXYTRITYL)-BETA-D-2-DEOXYRIBOFURANOSYL)-3-NITROPYRROLE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-O-(DIMETHOXYTRITYL)-BETA-D-2-DEOXYRIBOFURANOSYL)-3-NITROPYRROLE

There total 1 articles about 1-(5-O-(DIMETHOXYTRITYL)-BETA-D-2-DEOXYRIBOFURANOSYL)-3-NITROPYRROLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-(2'-deoxy-β-D-ribofuranosyl)-3-nitropyrrole (157066-48-3) → (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(3-nitro-1H-pyrrol-1-yl)tetrahydrofuran-3-ol (166984-63-0)

Guidance literature:

With pyridine; for 1h; Ambient temperature;

Reference yield: 79.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(3-nitro-1H-pyrrol-1-yl)tetrahydrofuran-3-ol (166984-63-0) → 1-(2'-deoxy-5'-dimethoxytrityl-β-D-ribofuranosyl)-3-nitropyrrole-3'-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.166667h;

Reference yield:

succinic acid anhydride (108-30-5) + (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(3-nitro-1H-pyrrol-1-yl)tetrahydrofuran-3-ol (166984-63-0) → 1-(5'-O-DMTr-2'-deoxy-β-D-ribofuranosyl)-3-nitropyrrole-3'-O-succinate

Guidance literature:

With pyridine; dmap; for 48h; Yield given; Ambient temperature;

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-(2'-deoxy-β-D-ribofuranosyl)-3-nitropyrrole

Refernces