(R/S)-1-(4-(methylsulfinyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Base Information

Chemical Name:(R/S)-1-(4-(methylsulfinyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one
CAS No.:1104449-46-8
Molecular Formula:C₂₄H₂₈N₄O₃S
Molecular Weight:452.577
Hs Code.:

Synonyms:(R/S)-1-(4-(methylsulfinyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

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Chemical Property of (R/S)-1-(4-(methylsulfinyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

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Technology Process of (R/S)-1-(4-(methylsulfinyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

There total 7 articles about (R/S)-1-(4-(methylsulfinyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1104449-29-7
1-(4-(methylthio)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

: 1104449-46-8
(R/S)-1-(4-(methylsulfinyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Guidance literature:: With m-chloroperoxybenzoic acid; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;
DOI:10.1021/jm501175v

Reference yield:

: 95798-23-5
1-(benzyloxycarbonyl)-4-hydroxypiperidine

: 1104449-46-8
(R/S)-1-(4-(methylsulfinyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 140 °C / Inert atmosphere

3: 5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 145 °C / Inert atmosphere

4: trimethylsilyl iodide / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 9 h / 100 °C / Inert atmosphere

6: m-chloroperoxybenzoic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With copper(l) iodide; m-chloroperoxybenzoic acid; trimethylsilyl iodide; 5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one; potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm501175v

Reference yield:

: 1104449-35-5
benzyl 4-(2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

: 1104449-46-8
(R/S)-1-(4-(methylsulfinyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 145 °C / Inert atmosphere

2: trimethylsilyl iodide / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 9 h / 100 °C / Inert atmosphere

4: m-chloroperoxybenzoic acid / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

With copper(l) iodide; m-chloroperoxybenzoic acid; trimethylsilyl iodide; 5-chloro-1-(2-fluoro-4-(methylsulfonyl)phenyl)-4-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one; potassium carbonate; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm501175v