(methylthio)methyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Base Information

Chemical Name:(methylthio)methyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate
CAS No.:1454288-94-8
Molecular Formula:C₂₁H₁₈BrF₃N₂O₄S₂
Molecular Weight:563.416
Hs Code.:

Synonyms:(methylthio)methyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

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Chemical Property of (methylthio)methyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

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Technology Process of (methylthio)methyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

There total 8 articles about (methylthio)methyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454288-93-7
(methylthio)methyl 2-(5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

: 1454288-94-8
(methylthio)methyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Guidance literature:: With N-Bromosuccinimide;

Reference yield:

: 219986-65-9
5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazole

: 1454288-94-8
(methylthio)methyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / acetonitrile / 6 h / 80 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

3: Oxone / methanol; water / 1.5 h / 20 °C

4: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 11 h / 20 - 100 °C

6: N-Bromosuccinimide

With Oxone; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; potassium carbonate; caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1454288-94-8
(methylthio)methyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: methanol / 1 h / Reflux

3.1: caesium carbonate / acetonitrile / 6 h / 80 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

5.1: Oxone / methanol; water / 1.5 h / 20 °C

6.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 11 h / 20 - 100 °C

8.1: N-Bromosuccinimide

With Oxone; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; potassium carbonate; caesium carbonate; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;