9α,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-11-taxen-13-one

Base Information

• Chemical Name: 9α,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-11-taxen-13-one
• CAS No.: 532935-96-9
• Molecular Formula: C₃₁H₃₈O₉
• Molecular Weight: 554.637
• Mol file: 532935-96-9.mol

Synonyms:9α,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-11-taxen-13-one

Chemical Property of 9α,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-11-taxen-13-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9α,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-11-taxen-13-one

There total 24 articles about 9α,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-11-taxen-13-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic anhydride (108-24-7) + 2α-benzoyloxy-5β,20-epoxy-4α,9α,10β-trihydroxy-11-taxen-13-one (532935-95-8) → 9α,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-11-taxen-13-one (532935-96-9)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1016/S0040-4020(03)00048-6

Reference yield:

2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-9α,10β-isopropylidenedioxy-11-taxen-13-one (532935-93-6) → 9α,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-11-taxen-13-one (532935-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 32 percent / AcOH / H₂O

2: 32 percent / pyridine

With pyridine; acetic acid; In water;

DOI:10.1016/j.bmcl.2006.09.068

Reference yield:

C39H44O7 (222844-42-0) → 9α,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-4α-hydroxy-11-taxen-13-one (532935-96-9)

Guidance literature:

Multi-step reaction with 8 steps

1: 76 percent / NH₂OH*HCl

2: 57 percent / OsO₄; NMO

3: 96 percent / pyridine

4: 39 percent / TBAF / tetrahydrofuran

5: 99 percent / DBU / toluene

6: 32 percent / AcOH / H₂O

7: 32 percent / pyridine

With pyridine; osmium(VIII) oxide; N-methyl-2-indolinone; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; water; toluene;

DOI:10.1016/j.bmcl.2006.09.068

upstream raw materials:

acetic anhydride

2α-benzoyloxy-5β,20-epoxy-4α,9α,10β-trihydroxy-11-taxen-13-one

C₃₉H₄₄O₇

C₃₀H₃₈O₆