3-cyclopropyl-7-(4-methoxyphenyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol

Base Information

Chemical Name:3-cyclopropyl-7-(4-methoxyphenyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol
CAS No.:1435518-35-6
Molecular Formula:C₂₀H₂₆O₂Si
Molecular Weight:326.511
Hs Code.:

Synonyms:3-cyclopropyl-7-(4-methoxyphenyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol

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Chemical Property of 3-cyclopropyl-7-(4-methoxyphenyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol

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Technology Process of 3-cyclopropyl-7-(4-methoxyphenyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol

There total 4 articles about 3-cyclopropyl-7-(4-methoxyphenyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1435518-15-2
1-cyclopropyl-5-(4-methoxyphenyl)pent-4-yn-1-one

: 1066-54-2
trimethylsilylacetylene

: 1435518-35-6
3-cyclopropyl-7-(4-methoxyphenyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol

Guidance literature:: trimethylsilylacetylene; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; Inert atmosphere;

1-cyclopropyl-5-(4-methoxyphenyl)pent-4-yn-1-one; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ja4032727

Reference yield:

: 1061175-68-5
5-(p-methoxyphenyl)pent-4-ynoic acid methyl ester

: 1435518-35-6
3-cyclopropyl-7-(4-methoxyphenyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / 1,4-dioxane; water / 20 °C / Inert atmosphere

2.1: 4-methyl-morpholine; dicyclohexyl-carbodiimide / dichloromethane / 15 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C / Inert atmosphere

4.2: 3 h / -78 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; n-butyllithium; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water;
DOI:10.1021/ja4032727

Reference yield:

: C₁₄H₁₇NO₃

: 1435518-35-6
3-cyclopropyl-7-(4-methoxyphenyl)-1-(trimethylsilyl)hepta-1,6-diyn-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; In tetrahydrofuran; cyclohexane;
DOI:10.1021/ja4032727