2-iodo-6-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

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Chemical Name:2-iodo-6-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one
CAS No.:960400-50-4
Molecular Formula:C₂₀H₂₃IN₂O₃S
Molecular Weight:498.385
Hs Code.:

Synonyms:2-iodo-6-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

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Chemical Property of 2-iodo-6-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

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Technology Process of 2-iodo-6-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

There total 5 articles about 2-iodo-6-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 960400-44-6
3-(2-hydroxy-ethyl)-5-iodo-thiophene-2-carboxylic acid [3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide

: 124-63-0
methanesulfonyl chloride

: 960400-50-4
2-iodo-6-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

Guidance literature:: 3-(2-hydroxy-ethyl)-5-iodo-thiophene-2-carboxylic acid [3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amide; methanesulfonyl chloride; With triethylamine; In dichloromethane; at 0 ℃;

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 28424-70-6
4,5-dihydro-7H-thieno[2,3-c]pyran-7-one

: 960400-50-4
2-iodo-6-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: [bis(acetoxy)iodo]benzene; iodine / tetrachloromethane / 0.17 h / 65 °C

2.1: trimethylaluminum / toluene / 0.08 - 0.17 h / 20 °C

2.2: 50 °C

2.3: 1 h / 20 °C

3.1: triethylamine / dichloromethane / 0 °C

3.2: 0 - 20 °C

With [bis(acetoxy)iodo]benzene; iodine; trimethylaluminum; triethylamine; In tetrachloromethane; dichloromethane; toluene;

Reference yield:

: 13781-67-4
3-(2-hydroxyethyl)thiophene

: 960400-50-4
2-iodo-6-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6-dihydro-4H-thieno[2,3-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 8 °C

2.1: aluminum (III) chloride / toluene / 1 h / 20 - 40 °C

3.1: [bis(acetoxy)iodo]benzene; iodine / tetrachloromethane / 0.17 h / 65 °C

4.1: trimethylaluminum / toluene / 0.08 - 0.17 h / 20 °C

4.2: 50 °C

4.3: 1 h / 20 °C

5.1: triethylamine / dichloromethane / 0 °C

5.2: 0 - 20 °C

With aluminum (III) chloride; [bis(acetoxy)iodo]benzene; iodine; trimethylaluminum; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrachloromethane; dichloromethane; toluene; 2.1: Friedel Crafts Acylation;