(S)-(+)-2-Aminobutane

Base Information

• Chemical Name: (S)-(+)-2-Aminobutane
• CAS No.: 513-49-5
• Molecular Formula: C4H11 N
• Molecular Weight: 73.138
• Hs Code.: 2921199090
• Mol file: 513-49-5.mol

Synonyms:2-Butanamine,(S)-; sec-Butylamine, (S)- (8CI); (+)-(S)-sec-Butylamine; (+)-2-Aminobutane;(+)-2-Butylamine; (+)-sec-Butylamine; (1S)-1-Methylpropylamine;(S)-(+)-2-Aminobutane; (S)-(+)-2-Butylamine; (S)-(+)-sec-Butylamine;(S)-1-Methylpropylamine; (S)-2-Aminobutane; (S)-2-Butanamine; (S)-2-Butylamine;(S)-N-sec-Butylamine; (S)-sec-Butylamine; [(1S)-1-Methylpropyl]amine

Chemical Property of (S)-(+)-2-Aminobutane

Chemical Property:

• Melting Point: -104 ºC
• Refractive Index: n20/D 1.393(lit.)
• Boiling Point: 63ºC(lit.)
• PKA: 10.74±0.10(Predicted)
• Flash Point: -19 ºC
• PSA: 26.02000
• Density: 0.731
• LogP: 1.44390
• Storage Temp.: Flammables area
• Sensitive.: Air Sensitive
• Water Solubility.: Fully miscible in water.

Purity/Quality:

98% ^*data from raw suppliers

(S)-2-Butanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,C,N,F+
• Statements: 11-34-50-35-20/22
• Safety Statements: 9-16-26-28-36/37/39-45-61-28A

MSDS Files:

Useful:

• Uses: It is an active pharmaceutical intermediate.

Technology Process of (S)-(+)-2-Aminobutane

There total 52 articles about (S)-(+)-2-Aminobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-(+)-2-benzyloxycarbonylaminobutane (98289-87-3) → (S)-2-aminobutane (513-49-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

butanone (78-93-3) → (S)-2-aminobutane (513-49-5) + (R)-sec-butylamine (13250-12-9)

Guidance literature:

With Escherichia coli overexpressing ω-transaminase from round 11 variant from Arthrobacter sp.; pyridoxal 5'-phosphate; isopropylamine; In dimethyl sulfoxide; at 45 ℃; pH=11; optical yield given as %ee; aq. buffer; Enzymatic reaction;

DOI:10.1002/adsc.201100558

Reference yield:

butanone (78-93-3) → (S)-2-aminobutane (513-49-5)

Guidance literature:

With L-alanin; Bacillus subtilis L-alanine dehydrogenase; NAD-specific formate dehydrogenase; ω-transaminase ATA-113; pyridoxal 5'-phosphate; ammonium formate; nicotiamide adenine dinucleotide; In dimethyl sulfoxide; at 30 ℃; for 24h; pH=7; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer;

DOI:10.1002/anie.200803763

upstream raw materials:

(S)-2-butyl azide

sec-butyl isothiocyanate

ethyl methyl ketone oxime

(S)-(+)-2-benzyloxycarbonylaminobutane

Downstream raw materials:

(S)-(+)-2-(2-Hydroxybenzylidenimino)-butan

(S)-N-(1-methylpropyl)benzamide

(R)-N-(1-methylpropyl)benzamide

(R)-N-((S)-sec-Butyl)-2-(4-chloro-2-methyl-phenoxy)-propionamide

Refernces

• 1、 Li, Jianjiong,Wang, Yingang,Wu, Qiaqing,Yao, Peiyuan,Yu, Shanshan,Zhu, Dunming. "Simultaneous Preparation of (S)-2-Aminobutane and d -Alanine or d -Homoalanine via Biocatalytic Transamination at High Substrate Concentration". supporting information. . Retrieved 2022/03/01.
• 2、 Yoon, Sanghan,Patil, Mahesh D.,Sarak, Sharad,Jeon, Hyunwoo,Kim, Geon-Hee,Khobragade, Taresh P.,Sung, Sihyong,Yun, Hyungdon. "Deracemization of Racemic Amines to Enantiopure (R)- and (S)-amines by Biocatalytic Cascade Employing ω-Transaminase and Amine Dehydrogenase". . p. 1898 - 1902. Retrieved 2019/02/27.