5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide

Base Information

• Chemical Name: 5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide
• CAS No.: 149912-96-9
• Molecular Formula: C₂₆H₂₇NO₃
• Molecular Weight: 401.505
• Mol file: 149912-96-9.mol

Synonyms:5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide

Chemical Property of 5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide

There total 1 articles about 5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-Diphenyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide (149912-95-8) + methyl iodide (74-88-4) → 5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide (149912-96-9)

Guidance literature:

With tert.-butyl lithium; Yield given. Multistep reaction;

Reference yield: 90.0%

5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide (149912-96-9) → 5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid (149912-97-0)

Guidance literature:

With dinitrogen tetraoxide;

Reference yield:

5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide (149912-96-9) → Trifluoro-methanesulfonic acid 5-methyl-4-oxo-2-phenyl-2-o-tolyl-7-[(E)-2-(1,6,8-trimethoxy-9,10-dioxo-3-trifluoromethanesulfonyloxy-9,10-dihydro-anthracen-2-yl)-vinyl]-4H-benzo[1,3]dioxin-8-yl ester

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / N₂O₄

2: 86 percent / CF₃COOH

3: 99 percent / ICl, Et₃N

4: 95 percent

5: 95 percent / Pd(CF₃COO)2, P(C₆H₅)3, i-Pr₂NH, CF₃COOAg / tetrahydrofuran / 90 °C

With palladium(II) trifluoroacetate; silver trifluoroacetate; Iodine monochloride; dinitrogen tetraoxide; triethylamine; diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran;

upstream raw materials:

2,2-Diphenyl-benzo[1,3]dioxole-4-carboxylic acid tert-butylamide

methyl iodide

Downstream raw materials:

5-Methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxole-4-carboxylic acid

8-Hydroxy-5-methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxin-4-one

8-Hydroxy-7-iodo-5-methyl-2-phenyl-2-o-tolyl-benzo[1,3]dioxin-4-one

Trifluoro-methanesulfonic acid 7-iodo-5-methyl-4-oxo-2-phenyl-2-o-tolyl-4H-benzo[1,3]dioxin-8-yl ester