3-(3-fluorophenyl)benzo[b]thiophene

Base Information

• Chemical Name: 3-(3-fluorophenyl)benzo[b]thiophene
• CAS No.: 147619-66-7
• Molecular Formula: C₁₄H₉FS
• Molecular Weight: 228.29
• Mol file: 147619-66-7.mol

Synonyms:3-(3-fluorophenyl)benzo[b]thiophene

Chemical Property of 3-(3-fluorophenyl)benzo[b]thiophene

Chemical Property:

Purity/Quality:

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Technology Process of 3-(3-fluorophenyl)benzo[b]thiophene

There total 2 articles about 3-(3-fluorophenyl)benzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-chlorofluorobenzene (625-98-9) + Benzo[b]thiophene (95-15-8,11095-43-5) → 3-(3-fluorophenyl)benzo[b]thiophene (147619-66-7)

Guidance literature:

With 5%-palladium/activated carbon; caesium carbonate; copper(l) chloride; In 1,4-dioxane; at 150 ℃; for 48h; Sealed tube;

DOI:10.1021/ja403130g

Reference yield: 38.0%

1-Fluoro-3-iodobenzene (1121-86-4) + benzo[b]thiophen-3-yl-3-boronic acid (113893-08-6) → 3-(3-fluorophenyl)benzo[b]thiophene (147619-66-7)

Guidance literature:

1-Fluoro-3-iodobenzene; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 20 ℃; for 0.333333h; Inert atmosphere;

benzo[b]thiophen-3-yl-3-boronic acid; With sodium hydrogencarbonate; In 1,4-dioxane; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.0c03723

Reference yield: 62.0%

3-(3-fluorophenyl)benzo[b]thiophene (147619-66-7) + 4-methoxy-phenol (150-76-5) → 2-(3-(3-fluorophenyl)benzo[b]thiophen-2-yl)-4-methoxyphenol

Guidance literature:

With tert-butylammonium hexafluorophosphate(V); In dichloromethane; at 25 ℃; for 3h; Electrochemical reaction; Inert atmosphere;

DOI:10.1039/d1ob01208h

upstream raw materials:

3-chlorofluorobenzene

Benzo[b]thiophene

1-Fluoro-3-iodobenzene

benzo[b]thiophen-3-yl-3-boronic acid