N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-4H-pyran-3-carboxamide

Base Information

• Chemical Name: N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-4H-pyran-3-carboxamide
• CAS No.: 1052114-93-8
• Molecular Formula: C₂₅H₁₅F₂N₃O₄
• Molecular Weight: 459.409

Synonyms:N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-4H-pyran-3-carboxamide

Chemical Property of N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-4H-pyran-3-carboxamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-4H-pyran-3-carboxamide

There total 1 articles about N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-4H-pyran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoro-4-((1H-pyrrolo [2,3-b]pyridin-4-yl)oxy)aniline (688781-75-1) + C12H6ClFO3 (1052114-92-7) → N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-4H-pyran-3-carboxamide (1052114-93-8)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1021/jm800476q

Reference yield: 61.0%

N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-4H-pyran-3-carboxamide (1052114-93-8) + Cyclopropylamine (765-30-0) → N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-cyclopropyl-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide (1052114-94-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 14h;

DOI:10.1021/jm800476q

Reference yield:

N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-4H-pyran-3-carboxamide (1052114-93-8) + 4-chloro-3-fluoroaniline (367-22-6) → N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(4-chloro-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide (1052114-96-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 14h;

DOI:10.1021/jm800476q

upstream raw materials:

3-fluoro-4-((1H-pyrrolo [2,3-b]pyridin-4-yl)oxy)aniline

C₁₂H₆ClFO₃

Downstream raw materials:

N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(4-chloro-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(3-fluoro-4-methoxyphenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-cyclopropyl-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

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