N-benzyl-3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline

Base Information

• Chemical Name: N-benzyl-3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline
• CAS No.: 1610999-15-9
• Molecular Formula: C₃₆H₄₃N₃O
• Molecular Weight: 533.757
• Mol file: 1610999-15-9.mol

Synonyms:N-benzyl-3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline

Chemical Property of N-benzyl-3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline

There total 5 articles about N-benzyl-3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline (1610998-79-2) + benzaldehyde (100-52-7) → N-benzyl-3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline (1610999-15-9)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 0 - 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2014.04.034

Reference yield:

N-[3-(benzyloxy)phenyl]-6-(4-phenylpiperazin-1-yl)hexanamide (1610998-68-9) → N-benzyl-3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline (1610999-15-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere; Reflux

2: acetic acid; sodium cyanoborohydride / methanol / 16 h / 0 - 20 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol;

DOI:10.1016/j.ejmech.2014.04.034

Reference yield:

N-[3-(benzyloxy)phenyl]-6-bromohexanamide (1610998-51-0) → N-benzyl-3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline (1610999-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere; Reflux

3: acetic acid; sodium cyanoborohydride / methanol / 16 h / 0 - 20 °C

With lithium aluminium tetrahydride; sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.04.034

upstream raw materials:

N-[3-(benzyloxy)phenyl]-6-bromohexanamide

N-[3-(benzyloxy)phenyl]-6-(4-phenylpiperazin-1-yl)hexanamide

3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline

benzaldehyde

Downstream raw materials:

3-{benzyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol hydrochloride

3-{benzyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol