N-{9-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2,3-dihydroxy-propoxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Base Information

• Chemical Name: N-{9-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2,3-dihydroxy-propoxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide
• CAS No.: 212061-62-6
• Molecular Formula: C₃₆H₄₁N₅O₇Si
• Molecular Weight: 683.836

Synonyms:N-{9-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2,3-dihydroxy-propoxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Chemical Property of N-{9-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2,3-dihydroxy-propoxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Chemical Property:

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Technology Process of N-{9-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2,3-dihydroxy-propoxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

There total 4 articles about N-{9-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2,3-dihydroxy-propoxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-O-allyl-N6-benzoyl-5'-O-(tert-butyldiphenylsilyl)adenosine (212061-31-9) → N-{9-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2,3-dihydroxy-propoxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (212061-62-6)

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In 1,4-dioxane; for 3h;

DOI:10.1021/jo0103975

Reference yield:

benzoyl chloride (98-88-4) → N-{9-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2,3-dihydroxy-propoxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (212061-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine N-oxide; OsO₄ / dioxane / 3 h

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In 1,4-dioxane;

DOI:10.1021/jo0103975

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → N-{9-[5-(tert-butyl-diphenyl-silanyloxymethyl)-3-(2,3-dihydroxy-propoxy)-4-hydroxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide (212061-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine N-oxide; OsO₄ / dioxane / 3 h

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In 1,4-dioxane;

DOI:10.1021/jo0103975

upstream raw materials:

2'-O-allyl-N⁶-benzoyl-5'-O-(tert-butyldiphenylsilyl)adenosine

benzoyl chloride

tert-butylchlorodiphenylsilane

adenosine

Downstream raw materials:

N⁶-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-[2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]ethyl]adenosine

N⁶-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-{2-[(N,N-dimethylamino)oxy]ethyl}adenosine

N⁶-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-{2-[(methyleneamino)oxy]ethyl}adenosine

N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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