1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol

Base Information

Chemical Name:1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol
CAS No.:1416805-42-9
Molecular Formula:C₁₉H₁₂ClF₄N₅O
Molecular Weight:437.784
Hs Code.:

Synonyms:1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol

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Chemical Property of 1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol

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Technology Process of 1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol

There total 4 articles about 1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 288-94-8
1H-tetrazole

: 1416805-93-0
C₁₈H₁₀ClF₄NO

: 1416805-42-9
1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol

: 1416805-30-5,1416805-94-1,1416805-95-2
1-(6-Chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 6h; Inert atmosphere;

Reference yield:

: 891842-50-5
2--bromo-6--chloroquinoline

: 1416805-42-9
1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper / dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / hexane; diethyl ether / 0.25 h / -70 °C / Inert atmosphere

2.2: -70 - 20 °C / Inert atmosphere

3.1: diethyl ether / -5 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 °C / Inert atmosphere

With n-butyllithium; copper; potassium carbonate; In diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1416805-92-9
C₁₇H₈ClF₄NO

: 1416805-42-9
1-(6-chloroquinolin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(2H-tetrazol-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / -5 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 °C / Inert atmosphere

With potassium carbonate; In diethyl ether; N,N-dimethyl-formamide;