ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOHEXANECARBOXYLATE

Base Information

• Chemical Name: ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOHEXANECARBOXYLATE
• CAS No.: 61586-78-5
• Molecular Formula: C9H16O3
• Molecular Weight: 172.224
• Hs Code.: 2918199090
• Mol file: 61586-78-5.mol

Synonyms:Cyclohexanecarboxylicacid, 2-hydroxy-, ethyl ester, (1R-cis)-;Ethyl (+)-(1R,2S)-2-hydroxycyclohexanecarboxylate;Ethyl (1R,2S)-(+)-2-hydroxycyclohexanecarboxylate;

Chemical Property of ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOHEXANECARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.00322mmHg at 25°C
• Refractive Index: n20/D 1.463
• Boiling Point: 251.4 °C at 760 mmHg
• Flash Point: 100.2 °C
• PSA: 46.53000
• Density: 1.093 g/cm³
• LogP: 1.10060
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(1R,2S)-Ethyl2-hydroxycyclohexanecarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOHEXANECARBOXYLATE

There total 51 articles about ETHYL (1R,2S)-CIS-2-HYDROXYCYCLOHEXANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl (1R,2S)-2-hydroxycyclohexane-1-carboxylate (61586-78-5)

Guidance literature:

In ethanol; at 25 ℃; prepared by the Kloeckera magna NRRL Y-1611;

DOI:10.1016/S0040-4039(00)84603-1

Reference yield: 90.2%

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl (1S,2R)-2-hydroxycyclohexanecarboxylate (119068-37-0) + ethyl anti-(1R,2R)-2-hydroxycyclohexanecarboxylate (119068-36-9) + ethyl (1S,2S)-2-hydroxycyclohexanecarboxylate (29569-79-7) + ethyl (1R,2S)-2-hydroxycyclohexane-1-carboxylate (61586-78-5)

Guidance literature:

With hydrogen; (benzene)>Cl; In dichloromethane; at 50 ℃; for 80h; under 76000.1 Torr; Product distribution; other solvent: ethanol;

DOI:10.1016/S0957-4166(00)82262-4

Reference yield: 80.0%

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl (1S,2S)-2-hydroxycyclohexanecarboxylate (29569-79-7) + ethyl (1R,2S)-2-hydroxycyclohexane-1-carboxylate (61586-78-5)

Guidance literature:

baker's yeast;

DOI:10.1016/0957-4166(95)00408-4

upstream raw materials:

ethanol

Salicylic acid

ethyl 2-oxocyclohexane carboxylate

sulfuric acid

Downstream raw materials:

ethyl (R)-1-(prop-2-enyl)-2-oxocyclohexanecarboxylate

ethyl (S)-1-allyl-2-oxocyclohexane-1-carboxylate

cyclohex-1-enecarboxylic acid ethyl ester

(1R,2S)-ethyl 2-(N-benzyl-N-((S)-α-methylbenzyl)amino)cyclohexanecarboxylate