ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate

Base Information

• Chemical Name: ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate
• CAS No.: 197708-30-8
• Molecular Formula: C₃₁H₄₂O₇
• Molecular Weight: 526.67
• Mol file: 197708-30-8.mol

Synonyms:ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate

Chemical Property of ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate

There total 13 articles about ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl-5-(coumarin-7-yl)oxypentanoate (155791-63-2) → ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate (197708-30-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) 25 deg C, 30 min, 2.) EtOH, reflux, 4 h

2: 95 percent / H₂ / 5percent Pd/C / ethanol / 1 h / 25 °C / 760 Torr

3: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

With hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate (197708-28-4) → ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate (197708-30-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂ / 5percent Pd/C / ethanol / 1 h / 25 °C / 760 Torr

2: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

With hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) → ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate (197708-30-8)

Guidance literature:

Multi-step reaction with 7 steps

1: conc. sulfuric acid / 1 h / Heating

2: AlCl₃ / 1,2-dichloro-ethane / 2.5 h / 15 °C

3: 5N aq. NaOH / methanol / 1 h / 25 °C

4: NaBH₄ / methanol / 1 h / 25 - 65 °C

5: 73 percent / KCl / dimethylsulfoxide / 4 h / 170 °C

6: 92 percent / triethylamine / CH₂Cl₂ / 1 h

7: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; sulfuric acid; potassium chloride; sodium hydride; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1016/S0968-0896(97)00089-8

upstream raw materials:

(E)-6-(4-methoxyphenyl)-5-hexenyl methanesulfonate

ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-hydroxyphenoxy}-pentanoate

hexahydro-2H-oxepin-2-one

(5E)-6-(4-Methoxyphenyl)-5-hexen-1-ol