ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate

Base Information

• Chemical Name: ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate
• CAS No.: 197708-28-4
• Molecular Formula: C₁₈H₂₄O₆
• Molecular Weight: 336.385
• Mol file: 197708-28-4.mol

Synonyms:ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate

Chemical Property of ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate

There total 1 articles about ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + ethyl-5-(coumarin-7-yl)oxypentanoate (155791-63-2) → ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate (197708-28-4)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) 25 deg C, 30 min, 2.) EtOH, reflux, 4 h;

DOI:10.1016/S0968-0896(97)00089-8

Reference yield: 95.0%

ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate (197708-28-4) → ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-hydroxyphenoxy}-pentanoate (197708-29-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 25 ℃; for 1h; under 760 Torr;

DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

ethyl-5-{4-[2-(ethoxycarbonyl)-(E)-ethenyl]3-hydroxyphenoxy}pentanoate (197708-28-4) → 5-{4-(2-carboxyethyl)-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂ / 5percent Pd/C / ethanol / 1 h / 25 °C / 760 Torr

2: 1.) NaH / 1.) DMF, a) from 0 deg C to 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

3: 84 percent / aq. NaOH / ethanol / 1 h / Heating

With sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0968-0896(97)00089-8

upstream raw materials:

ethanol

ethyl-5-(coumarin-7-yl)oxypentanoate

Downstream raw materials:

ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-hydroxyphenoxy}-pentanoate

ethyl-5-{4-[2-(ethoxycarbonyl)ethyl]-3-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenoxy}pentanoate