L-ERYTHRONO-1,4-LACTONE

Base Information

• Chemical Name: L-ERYTHRONO-1,4-LACTONE
• CAS No.: 23732-40-3
• Molecular Formula: C4H6 O4
• Molecular Weight: 118.09
• Hs Code.: 2932209090
• Mol file: 23732-40-3.mol

Synonyms:2(3H)-Furanone,dihydro-3,4-dihydroxy-, (3S-cis)-; Erythronic acid, g-lactone, L- (8CI); L-Erythronic acid, g-lactone (6CI);(3S,4S)-3,4-Dihydroxydihydrofuran-2(3H)-one; L-Erythronolactone

Chemical Property of L-ERYTHRONO-1,4-LACTONE

Chemical Property:

• PSA: 66.76000
• LogP: -1.73500

Purity/Quality:

99% ^*data from raw suppliers

L-Erythrono-1,4-lactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Erythrono-1,4-lactone was studied as potential a α-glucosidase inhibitors.

Technology Process of L-ERYTHRONO-1,4-LACTONE

There total 8 articles about L-ERYTHRONO-1,4-LACTONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

meso-erythritol (909878-64-4,10030-58-7,188346-77-2,149-32-6) → γ lacton-of dl-erythronic acid (13092-55-2,15667-21-7,17675-99-9,21730-93-8,23732-40-3,23732-41-4,25596-90-1,114760-28-0)

Guidance literature:

With 1-Phenylbut-1-en-3-one; rhodium hydrido (PEt₃)3 complex; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

DOI:10.1055/s-1998-1705

Reference yield: 90.0%

D-threitol (2418-52-2,10030-58-7,188346-77-2,149-32-6) → DL-threonic acid-4-lactone (13092-55-2,15667-21-7,17675-99-9,21730-93-8,23732-40-3,23732-41-4,25596-90-1,114760-28-0)

Guidance literature:

With 1-Phenylbut-1-en-3-one; rhodium hydrido (PEt₃)3 complex; In N,N-dimethyl-formamide; at 60 - 80 ℃;

DOI:10.1055/s-1998-1705

Reference yield:

isoascorbic acid (89-65-6,98966-42-8) → oxalic acid (144-62-7,97993-78-7) + γ lacton-of dl-erythronic acid (13092-55-2,15667-21-7,17675-99-9,21730-93-8,23732-40-3,23732-41-4,25596-90-1,114760-28-0)

Guidance literature:

With oxygen; In methanol; at 25 ℃; for 1.5h; Product distribution; Mechanism; autooxidation L-ascorbic acid-related compounds;

DOI:10.1271/bbb.62.811

upstream raw materials:

(+/-)-erythronic acid

meso-erythritol

isoascorbic acid

D-threitol

Downstream raw materials:

(2S,3S)-benzyl 2,3,4-tri-(benzyloxy)butanoate

C₃₀H₂₆O₄

tartaric acid

meso-erythritol

Refernces

• 1、 Miyake, Noriko,Kurata, Tadao. "Autoxidation Reaction Mechanism for L-Ascorbic Acid-related Compounds in Methanol without Metal Ion Catalysis". . p. 811 - 813. Retrieved 2007/10/03.