ethyl [(4S)-6-(4-chlorophenyl)-1-methyl-8-(4-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

Base Information

Chemical Name:ethyl [(4S)-6-(4-chlorophenyl)-1-methyl-8-(4-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate
CAS No.:1352936-94-7
Molecular Formula:C₂₆H₂₂ClN₅O₂
Molecular Weight:471.946
Hs Code.:

Synonyms:ethyl [(4S)-6-(4-chlorophenyl)-1-methyl-8-(4-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

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Chemical Property of ethyl [(4S)-6-(4-chlorophenyl)-1-methyl-8-(4-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

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Technology Process of ethyl [(4S)-6-(4-chlorophenyl)-1-methyl-8-(4-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

There total 10 articles about ethyl [(4S)-6-(4-chlorophenyl)-1-methyl-8-(4-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352937-96-2
ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

: 1692-15-5
4-pyridylboronic acid

: 1352936-94-7
ethyl [(4S)-6-(4-chlorophenyl)-1-methyl-8-(4-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 120 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 1352936-94-7
ethyl [(4S)-6-(4-chlorophenyl)-1-methyl-8-(4-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 3.5 h / Reflux

2.1: toluene; diethyl ether / 1 h / 0 - 20 °C

3.1: chloroform / 1 h / 60 °C

4.1: triethylamine / dichloromethane / 24 h / Reflux

4.2: 2 h / 60 °C

5.1: sodium carbonate; phosphorus pentoxide / 1,2-dichloro-ethane / 2 h / 70 °C

6.1: hydrazine hydrate / tetrahydrofuran / 5 h / 0 - 15 °C

6.2: 16 h / 0 - 20 °C

7.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 20 °C

9.1: boron tribromide / dichloromethane / 0.42 h / -78 - 20 °C / Reflux

9.2: 3.5 h / Reflux

10.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1.5 h / 120 °C / Microwave irradiation

With phosphorus pentoxide; water; boron tribromide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; chloroform; water; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1300019-40-2
methyl 2-((4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-benzol[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)acetate

: 1352936-94-7
ethyl [(4S)-6-(4-chlorophenyl)-1-methyl-8-(4-pyridinyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 20 °C

2.1: boron tribromide / dichloromethane / 0.42 h / -78 - 20 °C / Reflux

2.2: 3.5 h / Reflux

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1.5 h / 120 °C / Microwave irradiation

With water; boron tribromide; sodium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;