ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

Base Information

Chemical Name:ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate
CAS No.:1352937-96-2
Molecular Formula:C₂₁H₁₉ClN₄O₃
Molecular Weight:410.86
Hs Code.:

Synonyms:ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

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Chemical Property of ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

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Technology Process of ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

There total 9 articles about ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 1300019-38-8
[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid

: 1352937-96-2
ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

Guidance literature:: [(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 0.416667h; Reflux;

ethanol; With sulfuric acid; In ethanol; dichloromethane; for 3.5h; Reflux;

Reference yield:

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 1352937-96-2
ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 3.5 h / Reflux

2.1: toluene; diethyl ether / 1 h / 0 - 20 °C

3.1: chloroform / 1 h / 60 °C

4.1: triethylamine / dichloromethane / 24 h / Reflux

4.2: 2 h / 60 °C

5.1: sodium carbonate; phosphorus pentoxide / 1,2-dichloro-ethane / 2 h / 70 °C

6.1: hydrazine hydrate / tetrahydrofuran / 5 h / 0 - 15 °C

6.2: 16 h / 0 - 20 °C

7.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 20 °C

9.1: boron tribromide / dichloromethane / 0.42 h / -78 - 20 °C / Reflux

9.2: 3.5 h / Reflux

With phosphorus pentoxide; water; boron tribromide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1300019-41-3,1300738-77-5
methyl 2-[(3S,2Z)-2-(acetylhydrazono)-5-(4-chlorophenyl)-7-(methyloxy)-1,3-dihydro-1,4-benzodiazepin-3-yl]acetate

: 1352937-96-2
ethyl[(4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / tetrahydrofuran / 48 h / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 5 h / 20 °C

3.1: boron tribromide / dichloromethane / 0.42 h / -78 - 20 °C / Reflux

3.2: 3.5 h / Reflux

With water; boron tribromide; acetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane;