(2R)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Base Information

• Chemical Name: (2R)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
• CAS No.: 177017-68-4
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• Hs Code.: 2922299090
• ChEMBL ID: CHEMBL1161325
• DSSTox Substance ID: DTXSID80511280
• Nikkaji Number: J1.311.136G
• Wikidata: Q82370011
• Mol file: 177017-68-4.mol

Synonyms:177017-68-4;(2R)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine;(R)-(+)-6-METHOXY 2-AMINOTETRALIN;CHEMBL1161325;(R)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine;2-Naphthalenamine, 1,2,3,4-tetrahydro-6-methoxy-, (2R)-;(R)-6-methoxy-2-aminotetralin;(2R)-6-Methoxytetralin-2-amine;6-methoxy-2-aminotetralin;DTXSID80511280;BDBM50474417;AKOS006273685;PD039219

Chemical Property of (2R)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Chemical Property:

• Vapor Pressure: 0.00118mmHg at 25°C
• Refractive Index: 1.547
• Boiling Point: 299.6 °C at 760 mmHg
• Flash Point: 139.7 °C
• PSA: 35.25000
• Density: 1.056 g/cm³
• LogP: 2.21150
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

(2R)-6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-2-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(CC(CC2)N)C=C1
• Isomeric SMILES: COC1=CC2=C(C[C@@H](CC2)N)C=C1

Technology Process of (2R)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

There total 21 articles about (2R)-6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-((R)-6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-isoindole-1,3-dione (281199-10-8) → 6-methoxy-2-aminotetralin (177017-69-5,177017-68-4)

Guidance literature:

With hydrazine; In ethanol;

DOI:10.1016/S0040-4039(00)00327-0

Reference yield: 60.0%

6-methoxy-3,4-dihydro-[1,2]-naphthoquinone-2-oxime (37563-97-6) → 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene (70312-05-9,70312-07-1,81861-30-5,177017-68-4,177017-69-5)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; at 50 ℃; for 20h; under 760.051 Torr;

DOI:10.3109/14756366.2014.940937

Reference yield: 50.0%

6-methoxy-2-tetralone (2472-22-2) → 2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene (70312-05-9,70312-07-1,81861-30-5,177017-68-4,177017-69-5)

Guidance literature:

6-methoxy-2-tetralone; With ammonium acetate; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; for 1 - 2h; Heating / reflux;

upstream raw materials:

terephthalonitrile

7-methoxy-1,2-dihydronaphthalene

6-methoxy-3,4-dihydro-[1,2]-naphthoquinone-2-oxime

6-Methoxy-3,4-dihydro-1H-naphthalen-2-one O-methyl-oxime

Downstream raw materials:

2-amino-1,2,3,4-tetrahydro-6-hydroxynaphthalene

2-amino-6-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride