(4R,6R)-4-[(R)-2-benzyloxy-4-(4-benzyloxyphenyl)butyl]-2,2-dimethyl-6-n-tridecyl-[1,3]dioxane

Base Information

Chemical Name:(4R,6R)-4-[(R)-2-benzyloxy-4-(4-benzyloxyphenyl)butyl]-2,2-dimethyl-6-n-tridecyl-[1,3]dioxane
CAS No.:913814-41-2
Molecular Formula:C₄₃H₆₂O₄
Molecular Weight:642.963
Hs Code.:

Synonyms:(4R,6R)-4-[(R)-2-benzyloxy-4-(4-benzyloxyphenyl)butyl]-2,2-dimethyl-6-n-tridecyl-[1,3]dioxane

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Chemical Property of (4R,6R)-4-[(R)-2-benzyloxy-4-(4-benzyloxyphenyl)butyl]-2,2-dimethyl-6-n-tridecyl-[1,3]dioxane

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Technology Process of (4R,6R)-4-[(R)-2-benzyloxy-4-(4-benzyloxyphenyl)butyl]-2,2-dimethyl-6-n-tridecyl-[1,3]dioxane

There total 6 articles about (4R,6R)-4-[(R)-2-benzyloxy-4-(4-benzyloxyphenyl)butyl]-2,2-dimethyl-6-n-tridecyl-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 913814-40-1
(3R,5S,7R)-3-benzyloxy-1-(4-benzyloxyphenyl)eicosane-5,7-diol

: 77-76-9
2,2-dimethoxy-propane

: 913814-41-2
(4R,6R)-4-[(R)-2-benzyloxy-4-(4-benzyloxyphenyl)butyl]-2,2-dimethyl-6-n-tridecyl-[1,3]dioxane

Guidance literature:: With 3 A molecular sieve; camphor-10-sulfonic acid; In acetone; at 20 ℃;
DOI:10.1016/j.tet.2006.07.076

Reference yield:

: 871809-93-7
(+)-(3R)-1-[4-(benzyloxy)phenyl]hex-5-en-3-ol

: 913814-41-2
(4R,6R)-4-[(R)-2-benzyloxy-4-(4-benzyloxyphenyl)butyl]-2,2-dimethyl-6-n-tridecyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 mg / sodium hydride; tetra-n-butyl ammonium iodide / tetrahydrofuran / 20 °C

2.1: 75 percent / CuCl; O₂ / PdCl₂ / dimethylformamide; H₂O / 48 h / 20 °C

3.1: Bu₂BOTf; ethyldiisopropylamine / CH₂Cl₂ / 1 h / -78 °C

3.2: 70 percent / CH₂Cl₂ / 3 h / -78 °C

4.1: 86 percent / tetramethylammonium triacetoxyborohydride; acetic acid / acetonitrile / 14 h / -30 - 0 °C

5.1: 89 percent / camphorsulfonic acid; molecular sieves 3 Angstroem / acetone / 20 °C

With 3 A molecular sieve; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; oxygen; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; copper(l) chloride; tetramethylammonium triacetoxyborohydride; palladium dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; 2.1: Wacker oxidation;
DOI:10.1016/j.tet.2006.07.076

Reference yield:

: 871809-94-8
(R)-4-benzyloxy-6-(4-benzyloxyphenyl)hex-1-ene

: 913814-41-2
(4R,6R)-4-[(R)-2-benzyloxy-4-(4-benzyloxyphenyl)butyl]-2,2-dimethyl-6-n-tridecyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / CuCl; O₂ / PdCl₂ / dimethylformamide; H₂O / 48 h / 20 °C

2.1: Bu₂BOTf; ethyldiisopropylamine / CH₂Cl₂ / 1 h / -78 °C

2.2: 70 percent / CH₂Cl₂ / 3 h / -78 °C

3.1: 86 percent / tetramethylammonium triacetoxyborohydride; acetic acid / acetonitrile / 14 h / -30 - 0 °C

4.1: 89 percent / camphorsulfonic acid; molecular sieves 3 Angstroem / acetone / 20 °C

With 3 A molecular sieve; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; oxygen; acetic acid; N-ethyl-N,N-diisopropylamine; copper(l) chloride; tetramethylammonium triacetoxyborohydride; palladium dichloride; In dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; 1.1: Wacker oxidation;
DOI:10.1016/j.tet.2006.07.076