(R)-3-tert-butoxycarbonylamino-4-(2-fluorophenyl)butyric acid 2,5-dioxopyrrolidin-1-yl ester

Base Information

• Chemical Name: (R)-3-tert-butoxycarbonylamino-4-(2-fluorophenyl)butyric acid 2,5-dioxopyrrolidin-1-yl ester
• CAS No.: 851307-02-3
• Molecular Formula: C₁₉H₂₃FN₂O₆
• Molecular Weight: 394.4

Synonyms:(R)-3-tert-butoxycarbonylamino-4-(2-fluorophenyl)butyric acid 2,5-dioxopyrrolidin-1-yl ester

Chemical Property of (R)-3-tert-butoxycarbonylamino-4-(2-fluorophenyl)butyric acid 2,5-dioxopyrrolidin-1-yl ester

Chemical Property:

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Technology Process of (R)-3-tert-butoxycarbonylamino-4-(2-fluorophenyl)butyric acid 2,5-dioxopyrrolidin-1-yl ester

There total 1 articles about (R)-3-tert-butoxycarbonylamino-4-(2-fluorophenyl)butyric acid 2,5-dioxopyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + (3R)-3-[(tert-butoxycarbonyl)amino]-4-(2-fluorophenyl)butanoic acid (218608-98-1,218608-99-2) → (R)-3-tert-butoxycarbonylamino-4-(2-fluorophenyl)butyric acid 2,5-dioxopyrrolidin-1-yl ester (851307-02-3)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield: 86.0%

3-amino-3,4-dihydro-1,5-naphthyridin-2-(1H)-one dihydrochloride (600157-67-3) + (R)-3-tert-butoxycarbonylamino-4-(2-fluorophenyl)butyric acid 2,5-dioxopyrrolidin-1-yl ester (851307-02-3) → tert-butyl {(1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2,3,4-tetrahydro-1,5-naphthyridin-3-yl)amino]propyl}carbamate (872322-47-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield: 78.0%

3-amino-1,2,3,4-tetrahydroquinolin-2-one (85115-10-2,40615-17-6) + (R)-3-tert-butoxycarbonylamino-4-(2-fluorophenyl)butyric acid 2,5-dioxopyrrolidin-1-yl ester (851307-02-3) → tert-butyl {(1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)amino]propyl}carbamate (872322-45-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 66h;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2-fluorophenyl)butanoic acid

Downstream raw materials:

{(R)-2-(2-fluorophenyl)-1-[((R)-1-methylcarbamoyl-2-thiophen-2-ylethylcarbamoyl)methyl]ethyl}carbamic acid tert-butyl ester

tert-butyl {(1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)amino]propyl}carbamate

tert-butyl {(1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2,3,4-tetrahydro-1,5-naphthyridin-3-yl)amino]propyl}carbamate

tert-butyl ((1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2,3,4-tetrahydro-1,8-naphthyridin-3-yl)amino]propyl)carbamate

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