6-METHYL-4-CHROMANONE

Base Information

• Chemical Name: 6-METHYL-4-CHROMANONE
• CAS No.: 39513-75-2
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Hs Code.: 2932999099
• Mol file: 39513-75-2.mol

Synonyms:4-Chromanone,6-methyl- (6CI);2,3-Dihydro-6-methyl-4H-1-Benzopyran-4-one;6-Methyl-2,3-dihydrobenzopyran-4-one;6-Methylchroman-4-one;6-Methylchromanone;

Chemical Property of 6-METHYL-4-CHROMANONE

Chemical Property:

• Vapor Pressure: 0.000949mmHg at 25°C
• Melting Point: 31-35 °C(lit.)
• Refractive Index: 1.555
• Boiling Point: 303.1 °C at 760 mmHg
• Flash Point: 145.4 °C
• PSA: 26.30000
• Density: 1.157 g/cm³
• LogP: 1.96020
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

6-Methyl-4-chromanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

• Uses: The product has been used as a substrate for carbonyl reductase from Sporobolomyces salmonicolor, wherein it was reduced to the corresponding (R)-chiral alcohol. It has also been used as a substrate for the enantioselective reduction by 3 biocatalysts, namely, Didymosphaeria igniaria, Coryneum betulinum and Chaetomium sp.

Technology Process of 6-METHYL-4-CHROMANONE

There total 24 articles about 6-METHYL-4-CHROMANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-methyl-chromen-4-one (38445-23-7) → 6-methyl-4-chromanone (39513-75-2)

Guidance literature:

With alpha-D-glucopyranose; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; In 1,2-dichloro-ethane; at 120 ℃; for 24h; chemoselective reaction;

DOI:10.1002/cssc.201801770

Reference yield: 92.0%

3-(4-methylphenoxy)propionic acid (25173-37-9) → 6-methyl-4-chromanone (39513-75-2)

Guidance literature:

With acid activated montmorillonite K-10; In toluene; for 0.416667h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2021.153372

Reference yield: 78.0%

C12H16O3 (1225533-42-5) → 6-methyl-4-chromanone (39513-75-2)

Guidance literature:

With ammonium cerium (IV) nitrate; In methanol; acetonitrile; at 70 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2012.05.112

upstream raw materials:

3-chloro-1-(2-hydroxy-5-methylphenyl)propan-1-one

3-(4-methylphenoxy)propionic acid

4-p-tolyloxy-but-2-yn-1-ol

4-chloro-6-methyl-2H-chromene

Downstream raw materials:

N-(6-methyl-chroman-4-ylidene)-N'-phenyl-hydrazine

7-methyl-2-phenylchroman-4-one

(E)-3-(4-methoxybenzylidene)chroman-4-one

(E)-6-methyl-3-(4-methoxybenzylidene)chroman-4-one

Refernces

• 1、 Begum, Ayisha F.,Balasubramanian, Kalpattu K.,Shanmugasundaram, Bhagavathy. "Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones". supporting information. . Retrieved 2021/09/13.
• 2、 Antonchick, Andrey P.,Manna, Srimanta. "Catalytic Transfer Hydrogenation Using Biomass as Hydrogen Source". . p. 3094 - 3098. Retrieved 2018/09/14.