2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(ethyloxycarbonyloxymethoxy)phosphonomethoxy]-ethyl}-purine

Base Information

Chemical Name:2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(ethyloxycarbonyloxymethoxy)phosphonomethoxy]-ethyl}-purine
CAS No.:1309973-12-3
Molecular Formula:C₂₃H₃₀N₅O₁₁PS
Molecular Weight:615.558
Hs Code.:

Synonyms:2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(ethyloxycarbonyloxymethoxy)phosphonomethoxy]-ethyl}-purine

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Chemical Property of 2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(ethyloxycarbonyloxymethoxy)phosphonomethoxy]-ethyl}-purine

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Technology Process of 2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(ethyloxycarbonyloxymethoxy)phosphonomethoxy]-ethyl}-purine

There total 3 articles about 2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(ethyloxycarbonyloxymethoxy)phosphonomethoxy]-ethyl}-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35179-98-7
chloromethyl ethyl carbonate

: GCD-189

: 1309973-12-3
2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(ethyloxycarbonyloxymethoxy)phosphonomethoxy]-ethyl}-purine

Guidance literature:: GCD-189; With triethylamine; In 1-Methylpyrrolidine; at 20 ℃; for 0.5h;

chloromethyl ethyl carbonate; In 1-Methylpyrrolidine; at 70 ℃; for 2h;

Reference yield:

: 183194-25-4
[[2-(2-amino-6-chloro-9H-purin-9-yl)ethoxy]methyl]phosphonic acid bis(1-methylethyl)ester

: 1309973-12-3
2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(ethyloxycarbonyloxymethoxy)phosphonomethoxy]-ethyl}-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 4 h / 20 - 70 °C / Inert atmosphere

2.1: trimethylsilyl bromide / acetonitrile / 20 °C

3.1: triethylamine / 1-Methylpyrrolidine / 0.5 h / 20 °C

3.2: 2 h / 70 °C

With trimethylsilyl bromide; triethylamine; In 1-Methylpyrrolidine; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1309973-34-9
2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine

: 1309973-12-3
2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(ethyloxycarbonyloxymethoxy)phosphonomethoxy]-ethyl}-purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl bromide / acetonitrile / 20 °C

2.1: triethylamine / 1-Methylpyrrolidine / 0.5 h / 20 °C

2.2: 2 h / 70 °C

With trimethylsilyl bromide; triethylamine; In 1-Methylpyrrolidine; acetonitrile;