2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine

Base Information

Chemical Name:2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine
CAS No.:1309973-34-9
Molecular Formula:C₂₁H₃₀N₅O₅PS
Molecular Weight:495.539
Hs Code.:

Synonyms:2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine

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Chemical Property of 2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine

Chemical Property:

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Technology Process of 2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine

There total 3 articles about 2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 696-63-9
4-Methoxybenzenethiol

: 183194-25-4
[[2-(2-amino-6-chloro-9H-purin-9-yl)ethoxy]methyl]phosphonic acid bis(1-methylethyl)ester

: 1309973-34-9
2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 4h; Inert atmosphere;

Reference yield:

: 116-17-6
triisopropyl phosphite

: 1309973-34-9
2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4 h / 90 - 125 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 80 °C

2.2: 8 h / 100 °C

3.1: triethylamine / N,N-dimethyl-formamide / 4 h / 20 - 70 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 151965-56-9
diisopropyl 2-(chloroethoxy)methylphosphonate

: 1309973-34-9
2-amino-6-(4-methoxyphenylthio)-9-{2-[bis(isopropyloxy)phosphonomethoxy]-ethyl}-purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 80 °C

1.2: 8 h / 100 °C

2.1: triethylamine / N,N-dimethyl-formamide / 4 h / 20 - 70 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In N,N-dimethyl-formamide;