2-Fluoro-6-methoxyphenol

Base Information

• Chemical Name: 2-Fluoro-6-methoxyphenol
• CAS No.: 73943-41-6
• Molecular Formula: C7H7FO2
• Molecular Weight: 142.13
• Hs Code.: 29095000
• European Community (EC) Number: 624-633-2
• DSSTox Substance ID: DTXSID20372019
• Nikkaji Number: J790.415K
• Wikidata: Q72474150
• Mol file: 73943-41-6.mol

Synonyms:2-Fluoro-6-methoxyphenol;73943-41-6;Phenol, 2-fluoro-6-methoxy-;MFCD00075140;2-Fluoro-6-methoxy-phenol;3-FLUORO-2-HYDROXYANISOLE;2-Methoxy-6-fluorophenol;2-methoxyl-6-fluorophenol;2-fluoro-6-methoxy phenol;SCHEMBL178550;DTXSID20372019;2-Fluoro-6-methoxyphenol, 97%;YZNHPLVFLRSVHY-UHFFFAOYSA-N;BBL102730;STL556536;AKOS005259582;CS-W011022;PS-9007;AM806813;SY109532;FT-0612395;EN300-56053;A19924;J-509492;Z850124378

Chemical Property of 2-Fluoro-6-methoxyphenol

Chemical Property:

• Appearance/Colour: Clear colorless to light brown liquid
• Vapor Pressure: 0.0627mmHg at 25°C
• Refractive Index: n20/D 1.52(lit.)
• Boiling Point: 224 °C at 760 mmHg
• PKA: 8.71±0.10(Predicted)
• Flash Point: 103.3 °C
• PSA: 29.46000
• Density: 1.224 g/cm³
• LogP: 1.53990
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 142.04300762
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-6-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC=C1)F)O

Technology Process of 2-Fluoro-6-methoxyphenol

There total 8 articles about 2-Fluoro-6-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-benzyloxy-3-fluoroanisole (914454-79-8) → 2-fluoro-6-methoxyphenol (73943-41-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;

DOI:10.1016/j.ejmech.2006.04.004

Reference yield: 69.0%

→ 2-fluoro-6-methoxyphenol (73943-41-6)

Guidance literature:

Reference yield:

1-fluoro-2,3-dimethoxybenzene (394-64-9) → 2-fluoro-6-methoxyphenol (73943-41-6) + 2-fluoro-6-hydroxyanisole (96994-70-6)

Guidance literature:

With niobium pentachloride; In 1,2-dichloro-ethane; for 1.5h; Title compound not separated from byproducts; Heating;

DOI:10.1002/ejoc.200500502

upstream raw materials:

1-fluoro-3-methoxybenzene

1-fluoro-2,3-dimethoxybenzene

2-benzyloxy-3-fluoroanisole

2-(benzyloxy)-3-fluorophenol

Downstream raw materials:

5-<(dimethylamino)methyl>-1-fluoro-2-hydroxy-3-methoxybenzene

Refernces

• 1、 Sudo, Yukinori,Arai, Shigeru,Nishida, Atsushi. "Facile and regioselective dealkylation of alkyl aryl ethers using niobium(V) pentachloride". . p. 752 - 758. Retrieved 2007/10/03.
• 2、 Adejare, Adeboye,Miller, Duane D.. "SYNTHESIS OF FLUORINATED BIPHENYLS VIA ARYNE REACTION". . p. 5597 - 5598. Retrieved 2007/10/02.