96994-70-6

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-2-methoxyphenol is used as a key intermediate in the synthesis of various pharmaceutical compounds, leveraging its chemical structure to contribute to the development of new drugs. Its unique properties allow it to be a versatile building block in medicinal chemistry, enhancing the therapeutic potential of resulting pharmaceuticals.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Fluoro-2-methoxyphenol is utilized as an intermediate for the production of various agrochemicals, including pesticides and herbicides. Its incorporation into these products can improve their efficacy and selectivity, contributing to more effective agricultural solutions.
Used in Fragrance and Flavoring Industry:
3-Fluoro-2-methoxyphenol is employed as an intermediate in the creation of fragrances and flavorings, capitalizing on its phenolic odor to add unique scents and tastes to a variety of consumer products. Its use in this industry is instrumental in developing novel and appealing sensory experiences for end-users.
Used in Research and Development:
3-Fluoro-2-methoxyphenol is also used in research and development settings, where its chemical properties are explored for potential applications in new areas of science and technology. Its reactivity and structural features make it a valuable compound for probing new chemical reactions and syntheses.

Upstream product

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Relevant academic research and scientific papers

A Mild meta-Selective C–H Alkylation of Catechol Mono-Ethers

Catechol mono-ethers are an important class of phenols. They are found in a number of pharmaceuticals, flavoring agents, perfumes, and are used for the preparation of numerous drugs. Herein, we report a mild meta-selective C–H alkylation of these phenols, which is enabled by a cascade of oxidative dearomatization – radical addition – rearomatization process. The method is compatible with reactive functional groups on the parent arenol, such as olefins and halides. Primary, secondary, and teriary alkyl groups can be used, the source of which is most commonly an alkylborane. This process is operationally simple, does not require heating and generally proceeds in good yields.

Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression

We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity for the GABAA receptor, together with a unique affinity for the NMDA receptor, different to propanidid and AZD3043. In animal models, compound 55 showed stronger hypnotic potency and longer duration of LORR than propanidid and AZD3043, but also maintained a rapid recovery time to walking and behavioral recovery. In particular, compound 55 displayed reflex depression during infusion.

Facile and regioselective dealkylation of alkyl aryl ethers using niobium(V) pentachloride

A simple and facile method for the cleavage of carbon-oxygen bonds promoted by niobium pentachloride(V) is described. Excellent yields and regioselectivities were observed with various alkyl aryl ethers to give the phenols. NMR studies revealed the formation of monoaryloxy niobium salt(V), and a neighboring-group effect may play a significant role in the regioselectivity. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.