6-benzyloxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one

Base Information

Chemical Name:6-benzyloxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one
CAS No.:1064201-75-7
Molecular Formula:C₂₄H₂₃NO₆S
Molecular Weight:453.516
Hs Code.:

Synonyms:6-benzyloxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one

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Chemical Property of 6-benzyloxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one

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Technology Process of 6-benzyloxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one

There total 4 articles about 6-benzyloxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 68360-26-9
6-benzyloxy-7-methoxy-3,4-dihydro-2H-isoquinolin-1-one

: 10130-74-2
m-Methoxybenzenesulfonyl chloride

: 1064201-75-7
6-benzyloxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: 6-benzyloxy-7-methoxy-3,4-dihydro-2H-isoquinolin-1-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 0.5h;

m-Methoxybenzenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 - 40 ℃; for 4h;
DOI:10.1002/cmdc.201400017

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 1064201-75-7
6-benzyloxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / water / 192 h / 140 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

3.1: methanesulfonic acid; sodium azide / dichloromethane / 16 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

4.2: 4 h / 20 - 40 °C

With piperidine; sodium azide; methanesulfonic acid; sodium hydride; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201400017

Reference yield:

: 127399-78-4
5-hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one

: 1064201-75-7
6-benzyloxy-7-methoxy-2-((3-methoxyphenyl)sulfonyl)-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2.1: methanesulfonic acid; sodium azide / dichloromethane / 16 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 50 °C

3.2: 4 h / 20 - 40 °C

With sodium azide; methanesulfonic acid; sodium hydride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201400017