5-<1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl>-2-methoxy-N-methylbenzenesulfonamide

Base Information

Chemical Name:5-<1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl>-2-methoxy-N-methylbenzenesulfonamide
CAS No.:70958-56-4
Molecular Formula:C₂₀H₂₈N₂O₄S*ClH
Molecular Weight:428.98
Hs Code.:

Synonyms:5-<1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl>-2-methoxy-N-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl>-2-methoxy-N-methylbenzenesulfonamide

Chemical Property:

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Technology Process of 5-<1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl>-2-methoxy-N-methylbenzenesulfonamide

There total 6 articles about 5-<1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl>-2-methoxy-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 344754-71-8
5-{2-[Benzyl-(1-methyl-3-phenyl-propyl)-amino]-1-hydroxy-ethyl}-2-methoxy-N-methyl-benzenesulfonamide

: 70958-56-4
5-<1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl>-2-methoxy-N-methylbenzenesulfonamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;
DOI:10.1248/cpb.30.4092

Reference yield:

: 6318-64-5
1-(3-amino-4-methoxyphenyl)ethan-1-one

: 70958-56-4
5-<1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl>-2-methoxy-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaNO₂, cc HCl 2.) CuCl₂*2H₂O, SO₂ / 1.) AcOH, 5 deg C, 30 min 2.) AcOH, 0-5 deg C

2: 94 percent / tetrahydrofuran / 5 °C

3: 87 percent / Bromine / acetic acid / 0.5 h / Ambient temperature

4: butan-2-one / Heating; 1-4 h

5: NaBH₄ / methanol / 2 h / Ambient temperature

6: 46 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; sulfur dioxide; hydrogen; bromine; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; butanone;
DOI:10.1248/cpb.30.4092

Reference yield:

: 85276-41-1
5-acetyl-2-methoxybenzenesulfonyl chloride

: 70958-56-4
5-<1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl>-2-methoxy-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / tetrahydrofuran / 5 °C

2: 87 percent / Bromine / acetic acid / 0.5 h / Ambient temperature

3: butan-2-one / Heating; 1-4 h

4: NaBH₄ / methanol / 2 h / Ambient temperature

5: 46 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; bromine; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; butanone;
DOI:10.1248/cpb.30.4092