Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate

Base Information

• Chemical Name: Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate
• CAS No.: 120145-37-1
• Molecular Formula: C₂₉H₃₆N₆O₇
• Molecular Weight: 580.641
• Mol file: 120145-37-1.mol

Synonyms:Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate

Chemical Property of Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate

There total 1 articles about Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl N-(p-aminobenzoyl)-L-glutamate (13726-52-8) + 2-pivaloyl-6-formyl-5-deazapterin (120040-44-0) → Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate (120145-37-1)

Guidance literature:

With triethylamine-borane; Yield given. Multistep reaction; 1) glacial acetic acid, 25 deg C, 14 h, 2) 25 deg C, 2 h;

DOI:10.1021/jm00127a019

Reference yield: 100.0%

acetyl chloride (75-36-5) + Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate (120145-37-1) → Diethyl N-pyrimidin-6-yl>methyl>-N10-acetyl-4-aminobenzoyl>glutamate (115499-19-9)

Guidance literature:

With sodium acetate; In dichloromethane; 1) 0 deg C, 15 min, 2) 25 deg C, 1 h;

DOI:10.1021/jm00127a019

Reference yield:

Diethyl N-pyrimidin-6-yl>methyl>-4-aminobenzoyl>glutamate (120145-37-1) → N-pyrimidin-6-yl)methyl>-N10-acetyl-4-aminobenzoyl>glutamic Acid

Guidance literature:

Multi-step reaction with 4 steps

1: acetic anhydride / 1.5 h / 25 °C

2: 83 percent / H₂ / PtO₂ / acetic acid / 3 h / 25 °C / 2585.7 Torr

3: 61 percent / aq. NaOH / 72 h / 25 °C

4: 23 percent / N,N-dimethyl-acetamide / 3 h / 25 °C

With sodium hydroxide; hydrogen; platinum(IV) oxide; In N,N-dimethyl acetamide; acetic anhydride; acetic acid;

DOI:10.1021/jm00127a019

upstream raw materials:

diethyl N-(p-aminobenzoyl)-L-glutamate

2-pivaloyl-6-formyl-5-deazapterin

Downstream raw materials:

Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-formyl-4-aminobenzoyl>glutamate

Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-acetyl-4-aminobenzoyl>glutamate

N-pyrimidin-6-yl)methyl>-4-aminobenzoyl>glutamic Acid

Diethyl N-pyrimidin-6-yl>methyl>-N¹⁰-formyl-4-aminobenzoyl>glutamate