4-(4-BROMOBENZOYL) MORPHOLINE

Base Information

• Chemical Name: 4-(4-BROMOBENZOYL) MORPHOLINE
• CAS No.: 127580-92-1
• Molecular Formula: C11H12BrNO2
• Molecular Weight: 270.126
• Hs Code.: 2934999090
• Mol file: 127580-92-1.mol

Synonyms:Morpholine,4-(4-bromobenzoyl)- (9CI);(4-Bromophenyl)(morpholin-4-yl)methanone;4-(4-Bromobenzoyl)morpholine;4-(Morpholine-4-carbonyl)bromobenzene;4-Bromobenzoic acid,morpholide;

Chemical Property of 4-(4-BROMOBENZOYL) MORPHOLINE

Chemical Property:

• Vapor Pressure: 1.45E-06mmHg at 25°C
• Refractive Index: 1.585
• Boiling Point: 398.7 °C at 760 mmHg
• PKA: -1.73±0.20(Predicted)
• Flash Point: 194.9 °C
• PSA: 29.54000
• Density: 1.486 g/cm³
• LogP: 1.85940
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(4-Bromophenyl)(morpholino)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-BROMOBENZOYL) MORPHOLINE

There total 36 articles about 4-(4-BROMOBENZOYL) MORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 4-Bromobenzoic acid (586-76-5) → (4-bromophenyl)(morpholino)methanone (127580-92-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1021/ja064782t

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + carbon monoxide (201230-82-2) + 1,4-bromoiodobenzene (589-87-7) → (4-bromophenyl)(morpholino)methanone (127580-92-1)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; triphenylphosphine; In 1,4-dioxane; at 100 ℃; for 20h; Inert atmosphere; Sealed tube; Cooling with ice;

DOI:10.1039/c9ra06594f

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + Ethyl 4-bromobenzoate (5798-75-4) → (4-bromophenyl)(morpholino)methanone (127580-92-1)

Guidance literature:

With potassium tert-butylate; In neat (no solvent); for 1h; Autoclave;

DOI:10.1002/anie.202106412

upstream raw materials:

4-(4-Bromothiobenzoyl)morpholine

4-acetylmorpholine

1.4-dibromobenzene

morpholine

Downstream raw materials:

(4-bromophenyl)-(3-methoxythiophen-2-yl)methanone

(4-(2-benzoylbenzofuran-3-yl)phenyl)(morpholino)-methanone

5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile

(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-quinazolin-6-yl)phenyl)(morpholino)methanone