(6-BROMO-PYRIDIN-2-YL)-PHENYL-METHANONE

Base Information

• Chemical Name: (6-BROMO-PYRIDIN-2-YL)-PHENYL-METHANONE
• CAS No.: 80100-16-9
• Molecular Formula: C12H14 Br N O
• Molecular Weight: 262.106
• Mol file: 80100-16-9.mol

Synonyms:Piperidine,1-(4-bromobenzoyl)- (9CI); Piperidine, 1-p-bromobenzoyl- (6CI);(4-Bromophenyl)(piperidin-1-yl)methanone

Chemical Property of (6-BROMO-PYRIDIN-2-YL)-PHENYL-METHANONE

Chemical Property:

• PSA: 29.96000
• LogP: 3.07510

Purity/Quality:

99% ^*data from raw suppliers

(6-Bromopyridin-3-yl)-phenylmethanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-BROMO-PYRIDIN-2-YL)-PHENYL-METHANONE

There total 6 articles about (6-BROMO-PYRIDIN-2-YL)-PHENYL-METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-bromonicotinic acid (6311-35-9) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (6-bromopyridin-3-yl)(phenyl)methanone (80100-16-9)

Guidance literature:

6-bromonicotinic acid; With thionyl chloride; for 3h; Reflux;

benzene; With aluminum (III) chloride; at 5 ℃; Reflux;

Reference yield: 77.0%

6-bromonicotinoyl chloride (740841-42-3) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (6-bromopyridin-3-yl)(phenyl)methanone (80100-16-9)

Guidance literature:

With aluminum (III) chloride; for 6h; Reflux;

Reference yield: 65.6%

2,5-dibromopyridine (624-28-2) + N,N-dimethylbenzamide (611-74-5) → (6-bromopyridin-3-yl)(phenyl)methanone (80100-16-9)

Guidance literature:

2,5-dibromopyridine; With n-butyllithium; In diethyl ether; hexane; at -75 ℃; for 0.5h;

N,N-dimethylbenzamide; In diethyl ether; hexane; for 0.583333h;

upstream raw materials:

2,5-dibromopyridine

N,N-dimethylbenzamide

6-bromonicotinoyl chloride

benzene

Downstream raw materials:

5-benzoyl-2-phenylpyridine

C₂₂H₂₁NO

(6-bromopyridin-3-yl)(phenyl)methanone oxime

(6-bromopyridin-3-yl)(phenyl)methylamine

Refernces

• 1、 Thimma Sambamoorthy, Manikandan,Rengan, Ramesh,Jan Grzegorz, Malecki. "Efficient construction of C–C bonds from aryl halides/aryl esters with arylboronic acids catalysed by palladium(II) thiourea complexes". . . Retrieved 2019/11/03.
• 2、 -. "SUBSTITUTED PYRIMIDINES". Page/Page column 45. . Retrieved 2013/04/10.