N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester

Base Information

Chemical Name:N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester
CAS No.:74219-73-1
Molecular Formula:C₃₇H₅₆N₂O₁₃
Molecular Weight:736.857
Hs Code.:

Synonyms:N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester

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Chemical Property of N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester

Chemical Property:

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Technology Process of N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester

There total 1 articles about N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 56877-43-1,60686-52-4
N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid

: 60686-53-5
γ,γ'-di-tert-butyl-D-γ-carboxyglutamic acid

: 74219-73-1
N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF, ether, 2.) 4 deg C, 2 d;
DOI:10.1021/ja00530a017

Reference yield: 97.0%

: 74219-73-1
N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester

: 74201-25-5
N-(benzyloxycarbonyl)-D-γ-carboxyglutamyl-D-γ-carboxyglutamic acid methyl ester

Guidance literature:: With trifluoroacetic acid; for 2h; Ambient temperature;
DOI:10.1021/ja00530a017

Reference yield:

: 74219-73-1
N-benzyloxycarbonyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamyl-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid methyl ester

: 80954-45-6
N-(benzyloxycarbonyl)-D-γ-methyleneglutamyl-D-γ-methyleneglutamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. TFA / 2 h / Ambient temperature

2: morpholine, TFA / H₂O / 0.33 h / Ambient temperature

With morpholine; trifluoroacetic acid; In water;
DOI:10.1021/jo00349a003