3-(3-sulfamoylphenyl)-N-(2,2,2-trifluoro-1-phenylethyl)-1H-indazole-5-carboxamide

Base Information

Chemical Name:3-(3-sulfamoylphenyl)-N-(2,2,2-trifluoro-1-phenylethyl)-1H-indazole-5-carboxamide
CAS No.:1338793-41-1
Molecular Formula:C₂₂H₁₇F₃N₄O₃S
Molecular Weight:474.463
Hs Code.:

Synonyms:3-(3-sulfamoylphenyl)-N-(2,2,2-trifluoro-1-phenylethyl)-1H-indazole-5-carboxamide

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Chemical Property of 3-(3-sulfamoylphenyl)-N-(2,2,2-trifluoro-1-phenylethyl)-1H-indazole-5-carboxamide

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Technology Process of 3-(3-sulfamoylphenyl)-N-(2,2,2-trifluoro-1-phenylethyl)-1H-indazole-5-carboxamide

There total 3 articles about 3-(3-sulfamoylphenyl)-N-(2,2,2-trifluoro-1-phenylethyl)-1H-indazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1338795-16-6
3-(3-sulfamoylphenyl)-1H-indazole-5-carboxylic acid

: 51586-24-4
1-amino-2,2,2-trifluoro-1-phenylethane

: 1338793-41-1
3-(3-sulfamoylphenyl)-N-(2,2,2-trifluoro-1-phenylethyl)-1H-indazole-5-carboxamide

Guidance literature:: 3-(3-sulfamoylphenyl)-1H-indazole-5-carboxylic acid; With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

1-amino-2,2,2-trifluoro-1-phenylethane; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With sodium methylate; In methanol; for 1h;

Reference yield:

: 486422-08-6
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide

: 1338793-41-1
3-(3-sulfamoylphenyl)-N-(2,2,2-trifluoro-1-phenylethyl)-1H-indazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; water / 3 h / 125 °C / Sealed; Inert atmosphere; Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine; isobutyl chloroformate / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 1 h / 20 °C

2.3: 1 h

With sodium carbonate; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 885271-25-0
3-iodo-1H-indazole-5-carboxylic acid methyl ester

: 1338793-41-1
3-(3-sulfamoylphenyl)-N-(2,2,2-trifluoro-1-phenylethyl)-1H-indazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; ethanol; water / 3 h / 125 °C / Sealed; Inert atmosphere; Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine; isobutyl chloroformate / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 1 h / 20 °C

2.3: 1 h

With sodium carbonate; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; N,N-dimethyl-formamide; toluene;