51586-24-4

Basic information

• Product Name: 2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE
• Synonyms: 2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE;alpha-(trifluoromethyl)benzylamine;α-(Trifluoromethyl)benzenemethanamine;Einecs 257-299-8;Benzenemethanamine, .alpha.-(trifluoromethyl)-;BenzeneMethanaMine, a-(trifluoroMethyl)-
• CAS NO: 51586-24-4
• Molecular Formula: C₈H₈F₃N
• Molecular Weight: 175.15
• EINECS: 257-299-8
• Mol File: 51586-24-4.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 196.418°C at 760 mmHg
• Flash Point: 78.877°C
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 0.399mmHg at 25°C
• Refractive Index: 1.468
• PKA: 6.15±0.10(Predicted)
• CAS DataBase Reference: 2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE(51586-24-4)
• EPA Substance Registry System: 2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE(51586-24-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 51586-24-4(Hazardous Substances Data)

Usage

General Description

2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE is a chemical compound with the molecular formula C8H8F3N. It belongs to the class of organic compounds known as trifluoromethylated aniline derivatives. 2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE is a colorless liquid with a strong ammonia-like odor. It is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceutical products. Additionally, it can also be used as a reagent in organic synthesis and chemical research. Due to its unique chemical properties and reactivity, 2,2,2-TRIFLUORO-1-PHENYL-ETHYLAMINE is a valuable compound in the field of organic chemistry.

InChI:InChI=1/C8H8F3N/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5,7H,12H2

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 655-25-4 2,2,2-trifluoroacetophenone oxime 
• 13652-09-0 (RS)-1-phenyl-2,2,2-trifluoroethylamine hydrochloride 
• 173668-33-2 N-2,2,2-trifluoro-1-phenylethyl-N-1'-(phenylethyl)amine 
• 53777-08-5 (S)-2-phenyl-butan-2-ol 
• 119561-20-5 N-benzylidene(1-phenyl-2,2,2-trifluoroethyl)amine 
• 67655-83-8 2,2,2-trifluoro-1-phenyl-ethanone oxime-O-(4-hydroxyphenylsulfonate) 
• 119561-19-2 N-(1-phenyl-2,2,2-trifluoroisopropylidene)benzylamine 
• 193202-45-8 2,2,2-Trifluoro-1-phenyl-ethanone O-benzyl-oxime 
• 134329-15-0 α-Methyl-N-<α-(trifluoromethyl)benzylidene>benzylamine 

Downstream Products

• 61290-83-3 1-(2-Hydroxy-ethyl)-1-methyl-3-(2,2,2-trifluoro-1-phenyl-ethyl)-thiourea 
• 65686-65-9 N-(α-phenyltrifluoroethyl) N'-(β-chloroethyl) Urea 
• 1201792-39-3 ethyl (2,2,2-trifluoro-1-phenylethylamino)acetate 
• 1246282-55-2 2,2-ditrifluoromethyl-N-(2,2,2-trifluoro-1-phenylethyl)-propanamide 
• 13652-07-8 phenyltrifluorodiazoethane 

Relevant articles and documents

Enantiomeric excess determination of α-amino acids by 19F NMR spectroscopy of their N,N-dimethyl-(2,2,2-trifluoro-1-phenylethyl)amine-C,N)palladium complexes

The synthesis and resolution of the trifluoromethyl-palladacycle, di-μ-chloro-bis(N,N-dimethyl-(2,2,2-trifluoro-1-phenylethyl)amine-2-C,N) palladium(II) are shown. The utility of the complex and its application in the enantiomeric excess determination of α-amino acids by 19F NMR spectroscopy is demonstrated and X-ray diffraction analysis of one of the diastereomeric complexes, trans-{[(R)-phenylglycinato-N,O][(R)-N,N-dimethyl-(2,2,2-trifluoro-1- phenylethyl)amine-C,N]palladium(II)}, is reported.

Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors

NLRP3 inflammasome mediated release of interleukin-1β (IL-1β) has been implicated in various diseases. In this study, rationally designed mimics of sulfonylurea moiety were investigated as NLRP3 inhibitors. Our results culminated into discovery of series of unprecedented N-cyano sulfoximineurea derivatives as potent NLRP3 inflammasome inhibitors. Compound 15 (IC50 = 7 nM) and analogues were found to be highly potent and selective NLRP3 inflammasome inhibitor with good pharmacokinetic profile. These effects translate in vivo, as 15, 29, and 34 significantly inhibit NLRP3 dependent IL-1β secretion in mice.

IDO inhibitors

The invention discloses novel compounds used as indoleeamine-pyrrole-2,3-dioxygenase (IDO) inhibitors, and specifically discloses the compounds represented by a formula (I) shown in the description and pharmaceutically-acceptable salts of the compounds. The invention also discloses an application of the compounds represented by the formula (I) and the pharmaceutically-acceptable salts of the compounds in preparation of a medicament for treating tumors.