(S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2-oxo-ethyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2-oxo-ethyl ester
CAS No.:203922-27-4
Molecular Formula:C₂₈H₂₇NO₈
Molecular Weight:505.524
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2-oxo-ethyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2-oxo-ethyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2-oxo-ethyl ester

There total 18 articles about (S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2-oxo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: C₃₂H₃₇NO₉

: 203922-27-4
(S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2-oxo-ethyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; water; at 10 ℃; for 1h;

Reference yield:

: 182201-50-9
(S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2,2-dimethoxy-ethyl ester

: 203922-27-4
(S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2-oxo-ethyl ester

Guidance literature:: With boron trifluoride diethyl etherate; water; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1021/ja962480t

Reference yield:

: 100-39-0
benzyl bromide

: 203922-27-4
(S)-2-Benzyloxycarbonylamino-3-(6-benzyloxy-7-methyl-benzo[1,3]dioxol-5-yl)-propionic acid 2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 23 deg C, 40 min

2: 99 percent / piperidine, acetic acid / benzene / 18 h / 23 °C

3: 94 percent / Et₃N, HCOOH, Pd(PPh₃)4 / 4 h / 23 °C

4: (PhO)2P(O)N₃, Et₃N, 4 Angstroem molecular sieves / toluene / 2 h / 70 °C

5: 1 h / 23 °C

6: 97 percent / H₂, Rh<(COD)-(R,R)-DIPAMP>(+)*BF₄(-) / 16 h / 23 °C / 2280 Torr

7: BF₃*Et₂O, H₂O / CH₂Cl₂ / 0.17 h / 0 °C

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; formic acid; Rh<(COD)-(R,R)-DIPAMP>(+)*BF4(-); 4 A molecular sieve; diphenyl phosphoryl azide; boron trifluoride diethyl etherate; water; hydrogen; sodium hydride; acetic acid; triethylamine; In dichloromethane; toluene; benzene;
DOI:10.1021/ja962480t