pitavastatin potassium

Base Information

Chemical Name:pitavastatin potassium
CAS No.:192565-91-6
Molecular Formula:C₂₅H₂₃FNO₄*K
Molecular Weight:459.559
Hs Code.:

Synonyms:pitavastatin potassium

Suppliers and Price of pitavastatin potassium

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of pitavastatin potassium

Chemical Property:

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Technology Process of pitavastatin potassium

There total 5 articles about pitavastatin potassium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147489-06-3
(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester

: 192565-91-6
pitavastatin potassium

Guidance literature:: (4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester; With hydrogenchloride; water; In methanol; at 25 ℃; for 8h;

With sodium hydroxide; In methanol; water; at 15 ℃;

With potassium hydroxide; In water; at 25 ℃; for 0.5h;

Reference yield:

: 147526-32-7,147511-69-1,688735-41-3,769908-13-6,121659-03-8
pitavastatin

: 192565-91-6
pitavastatin potassium

Guidance literature:: With potassium hydroxide; In isopropyl alcohol; at 25 - 35 ℃;

Reference yield:

: 121660-11-5
2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline

: 192565-91-6
pitavastatin potassium

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 25 °C / Industry scale

1.2: pH 7 - 8

2.1: isopropyl alcohol; toluene / 4 h / 25 - 50 °C / Industry scale

3.1: potassium carbonate / dimethyl sulfoxide / 10 h / 25 °C

4.1: hydrogenchloride; water / methanol / 8 h / 25 °C

4.2: 15 °C

4.3: 0.5 h / 25 °C

With hydrogenchloride; water; phosphorus tribromide; potassium carbonate; In methanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; toluene;