Technology Process of pitavastatin potassium
There total 5 articles about pitavastatin potassium which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester;
With
hydrogenchloride; water;
In
methanol;
at 25 ℃;
for 8h;
With
sodium hydroxide;
In
methanol; water;
at 15 ℃;
With
potassium hydroxide;
In
water;
at 25 ℃;
for 0.5h;
- Guidance literature:
-
With
potassium hydroxide;
In
isopropyl alcohol;
at 25 - 35 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 25 °C / Industry scale
1.2: pH 7 - 8
2.1: isopropyl alcohol; toluene / 4 h / 25 - 50 °C / Industry scale
3.1: potassium carbonate / dimethyl sulfoxide / 10 h / 25 °C
4.1: hydrogenchloride; water / methanol / 8 h / 25 °C
4.2: 15 °C
4.3: 0.5 h / 25 °C
With
hydrogenchloride; water; phosphorus tribromide; potassium carbonate;
In
methanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; toluene;
![(4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester](/Databaselist/images/loading.webp)
