5'-O-dimethoxytrityl-2'-O-methyl-N²-(N',N'-dimethylformamidine)isocytidine

Base Information

• Chemical Name: 5'-O-dimethoxytrityl-2'-O-methyl-N²-(N',N'-dimethylformamidine)isocytidine
• CAS No.: 175471-67-7
• Molecular Formula: C₃₄H₃₈N₄O₇
• Molecular Weight: 614.698
• Mol file: 175471-67-7.mol

Synonyms:5'-O-dimethoxytrityl-2'-O-methyl-N²-(N',N'-dimethylformamidine)isocytidine

Chemical Property of 5'-O-dimethoxytrityl-2'-O-methyl-N²-(N',N'-dimethylformamidine)isocytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-dimethoxytrityl-2'-O-methyl-N²-(N',N'-dimethylformamidine)isocytidine

There total 5 articles about 5'-O-dimethoxytrityl-2'-O-methyl-N²-(N',N'-dimethylformamidine)isocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-O-methyl-N2-(N',N'-dimethylformamidine)isocytidine (175471-66-6) → 5'-O-dimethoxytrityl-2'-O-methyl-N2-(N',N'-dimethylformamidine)isocytidine (175471-67-7)

Guidance literature:

With dmap; triethylamine; In pyridine; for 8h;

DOI:10.1080/07328319608002392

Reference yield:

2'-O-methyl-5'-O-p-tolylsulfonyluridine (175471-63-3) → 5'-O-dimethoxytrityl-2'-O-methyl-N2-(N',N'-dimethylformamidine)isocytidine (175471-67-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / DBU / acetonitrile / 48 h / Heating

2: 85 percent / NH₃ / methanol / 120 h / Ambient temperature

3: 80 percent / dimethylformamide / 1 h / Ambient temperature

4: 85 percent / 4-dimethylaminopyridine, triethylamine / pyridine / 8 h

With dmap; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In pyridine; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1080/07328319608002392

Reference yield:

2'-O-methyl-2,5'-anhydrouridine (175471-64-4) → 5'-O-dimethoxytrityl-2'-O-methyl-N2-(N',N'-dimethylformamidine)isocytidine (175471-67-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / NH₃ / methanol / 120 h / Ambient temperature

2: 80 percent / dimethylformamide / 1 h / Ambient temperature

3: 85 percent / 4-dimethylaminopyridine, triethylamine / pyridine / 8 h

With dmap; ammonia; triethylamine; In pyridine; methanol; N,N-dimethyl-formamide;

DOI:10.1080/07328319608002392

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-O-methyl-N²-(N',N'-dimethylformamidine)isocytidine

2'-O-methyl-2,5'-anhydrouridine

2'-O-methylisocytidine