3-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-5-fluoro-benzonitrile

Base Information

Chemical Name:3-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-5-fluoro-benzonitrile
CAS No.:1146733-66-5
Molecular Formula:C₁₇H₁₁FN₂O₃
Molecular Weight:310.284
Hs Code.:

Synonyms:3-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-5-fluoro-benzonitrile

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Chemical Property of 3-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-5-fluoro-benzonitrile

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Technology Process of 3-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-5-fluoro-benzonitrile

There total 5 articles about 3-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-5-fluoro-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1146733-64-3
3-fluoro-5-(4-methyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-benzonitrile

: 74-88-4
methyl iodide

: 1146733-66-5
3-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-5-fluoro-benzonitrile

Guidance literature:: 3-fluoro-5-(4-methyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

Reference yield:

: 1064396-14-0
3-cyano-5-fluoro-benzoic acid chloride

: 1146733-66-5
3-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-5-fluoro-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 1.5 h / 125 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 1 h / 20 °C

With aluminum (III) chloride; sodium hydride; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 327056-74-6
3-cyano-5-fluorobenzoic acid

: 1146733-66-5
3-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-5-fluoro-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride

2.1: aluminum (III) chloride / 1.5 h / 125 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 1 h / 20 °C

With aluminum (III) chloride; thionyl chloride; sodium hydride; In N,N-dimethyl-formamide; mineral oil;