(S,E)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide

Base Information

• Chemical Name: (S,E)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide
• CAS No.: 1067073-65-7
• Molecular Formula: C₁₄H₁₇NO₅
• Molecular Weight: 279.293
• Mol file: 1067073-65-7.mol

Synonyms:(S,E)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide

Chemical Property of (S,E)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,E)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide

There total 1 articles about (S,E)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-N-hydroxy-α-methyl-benzenemethanamine ethanedioate (78798-33-1) + dimethyl acetylenedicarboxylate (762-42-5) → (S,E)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide (1067073-65-7)

Guidance literature:

With sodium acetate trihydrate; In methanol; at 0 - 20 ℃;

DOI:10.1021/ol8017243

Reference yield: 99.0%

(S,E)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide (1067073-65-7) + ethyl vinyl ether (109-92-2,25104-37-4) → methyl (3S*,5R*)-5-ethoxy-3-(2-methoxy-2-oxoethyl)-2-((S)-1-phenylethyl)isoxazolidine-3-carboxylate

Guidance literature:

at 90 ℃; for 72h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol8017243

Reference yield: 92.0%

tert-butyl vinyl ether (926-02-3) + (S,E)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide (1067073-65-7) → methyl (3S*,5R*)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)-2-((S)-1-phenylethyl)isoxazolidine-3-carboxylate

Guidance literature:

at 90 ℃; for 72h; Inert atmosphere;

DOI:10.1021/ol8017243

upstream raw materials:

(S)-N-hydroxy-α-methyl-benzenemethanamine ethanedioate

dimethyl acetylenedicarboxylate